关键词: 卵巢肿瘤, 肿瘤转移, 肿瘤侵润, 预后, 肿瘤间质

Abstract: The tumor stroma consists of stromal myofibroblasts，endothelial cells，and leukocytes. A large amount of evidence indicates that tumor stroma could produce proteases，growth factors，immune response-modulating proteins and so on and respond to stimuli initiated in the tumor cells to establish a bi-directional communication network in the microenvironment to promote tumor cell proliferation，apoptosis，cell adhesion and tumor invasion. They are closely related to tumor growth and progression. Recently，studies indicate that tumor stroma played an important role in the development and invasion and metastasis of ovarian cancer，and is related to clinicopathological characteristics and prognosis of ovarian cancer. Tumor stroma has been regarded as a hot target for biological intervention in treatment of ovarian cancer.

Key words: Ovarian neoplasms, Neoplasm metastasis, Neoplasm invasiveness, Prognosis, Tumor stroma