国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (1): 95-97.

• 论著 • 上一篇    下一篇

RECK与MMP-9基因在子宫内膜癌中的表达及临床意义

刘晶晶, 顾振鹏, 姚丽娟, 李 攀, 刘志慧   

  1. 256603 山东省滨州市,滨州医学院附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-02-15 发布日期:2012-02-15
  • 通讯作者: 顾振鹏

Expression of RECK and MMP-9 in Endometrial Carcinoma and Its Clinical Significance

LIU Jing-jing，GU Zhen-peng，YAO Li-juan，LI Pan，LIU Zhi-hui   

  1. Department of Obstetrics and Gynecology，Affiliated Hospital of Binzhou Medical University，Binzhou 256603，Shandong Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-02-15 Online:2012-02-15
  • Contact: GU Zhen-peng

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摘要： 目的：研究RECK和MMP-9在不同子宫内膜组织中的表达，探讨两者在子宫内膜癌的发生、发展和浸润转移中的作用。方法：应用链霉菌抗生物素蛋白-过氧化酶（SP）免疫组化法检测42例子宫内膜癌组织、15例子宫内膜不典型增生组织及26例正常增生期子宫内膜组织中RECK蛋白及MMP-9蛋白表达情况。结果：与正常增生期子宫内膜组织及子宫内膜不典型增生组织相比，子宫内膜癌组织中RECK蛋白阳性表达率显著降低（χ2=9.307，P＜0.05），MMP-9蛋白阳性表达率显著增高（χ2=11.438，P＜0.05），RECK蛋白与MMP-9蛋白在子宫内膜癌中的表达存在明显负相关（P＜0.01）。RECK蛋白的表达水平与临床分期、组织学分级、肌层浸润深度及淋巴结转移密切相关（均P＜0.05）；MMP-9蛋白的表达水平与临床分期、组织学分级、肌层浸润深度密切相关（均P＜0.05），而与淋巴结转移无关。结论：RECK蛋白的表达缺失和MMP-9的表达可能与子宫内膜癌的发生、发展及浸润转移有关。

关键词: 子宫内膜肿瘤, 癌, 子宫内膜样, 膜糖蛋白类, 基质金属蛋白酶9, 肿瘤侵润, 肿瘤转移

Abstract: Objective：Study the expression of reversion-inducing cysteine-rich protein with Kazal motifs（RECK） and
matrix metalloproteinase-9（MMP-9） in different endometrial tissues and study their roles of invasion and metabasis in endometrial carcinoma. Methods：The expression of RECK and MMP-9 were detected in 42 cases of endometrial carcinomas， 15 cases of atypical hyperplasia and 26 cases of proliferative endometrium by S-P immumohistochemical technique. Results：Compared with atypical hyperplasia and proliferative endometrium groups，the positive rate of RECK protein in endometrial carcinoma was significantly lower（χ2=9.307，P＜0.05）and the positive rate of MMP-9 protein was obviously higher（χ2=11.438，P＜0.05）. There existed obviously negative correlation between the expressions of RECK and MMP-9（P＜0.01）.In endometrial carcinomas; the positive rate of RECK protein was positively related to FIGO stage，histologic grade and depth of myometrial invasion（P＜0.05）.However，the expression rate of MMP-9 protein did not correlate with
lymphatic metastasis，but it correlated with FIGO stage，histologic grade and depth of myometrial invasion（P＜0.05）.
Conclusions：RECK and MMP-9 may play important roles in the invasion and metastasis of endometrial carcinoma.

Key words: Endometrial neoplasms, Carcinoma, endometrioid, Membrane glycoproteins, Matrix metalloproteinase9, Neoplasm invasiveness