国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (3): 218-220.

• 综述 • 上一篇    下一篇

妊娠合并重症肌无力的临床研究进展

华绍芳，韩玉环   

  1. 300211 天津医科大学第二医院产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-06-15 发布日期:2014-06-15

The Research Progress of Pregnancy Complicated with Myasthenia Gravis

HUA Shao-fang，HAN Yu-huan   

  1. Department of Obstetrics，the Second Hospital of Tianjin Medical University，Tianjin 300211，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-06-15 Online:2014-06-15

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被引次数

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摘要： 重症肌无力（myasthenia gravis，MG）是神经-肌肉接头传递障碍并以骨骼肌无力为特征的自身免疫性疾病。妊娠合并MG可使病情发生难以预测的变化。妊娠妇女MG病情、治疗方案对胎儿、新生儿、甚至子代的远期存在一定影响。MG与妊娠、分娩、麻醉等过程存在相互作用。妊娠期用药应采取个体化治疗方案；MG病情控制良好的妊娠妇女仅在有产科指征时方可考虑剖宫产术，阴道分娩则应尽可能缩短第二产程。MG妊娠妇女的围生期治疗需要特殊关注。综述如上问题的研究进展。

关键词: 妊娠, 重症肌无力, 围生期医护, 治疗

Abstract: Myasthenia gravis （MG） is an autoimmune disease of the neuromuscular junction characterized by skeletal muscle weakness. The course of MG during pregnancy is unpredictable. The stage and medication of MG will have effects on fetus，neonate and long-term outcome of the offspring. There will be an interaction between MG and pregnancy，partum，anaesthesia. The patients should be given individual regimen during pregnancy. If well-controlled，the patient will undergo caesarean section only with obstetric indication. The duration should be shortened by forceps when vaginal delivery. Strict surveillance and therapeutic regimen are crucial to the pregnant women with MG. This article reviews the advances on clinical research in pregnancy complicated with MG.

Key words: Pregn, Myasthenia gravis, Perinatal care, Therapy