国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (1): 12-15.

• 综述 • 上一篇    下一篇

血管内皮祖细胞与妊娠的研究进展

孙礼强, 徐先明   

  1. 200080 上海交通大学附属第一人民医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-02-15 发布日期:2010-02-15

Research of Endothelial Progenitor Cell in Pregnancy

SUN Li-qiang，XU Xian-ming   

  1. Department of Obstetrics and Gynecology, the First Affiliated People’s Hospital , Shanghai Jiaotong University，Shanghai 200080, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-02-15 Online:2010-02-15

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4990

被引次数

2

摘要： 血管内皮祖细胞（endothelial progenitor cells，EPC）是血管内皮细胞的前体细胞，主要来源于骨髓、脐血、成人外周血，不仅参与胚胎血管形成，而且在出生后的血管生成过程中有重要的促进作用。妊娠是对母体血液循环系统的巨大挑战，需要机体系统性地适应和子宫发生足够变化。子痫前期患者及妊娠期糖尿病患者中多存在内皮功能的失衡。就近年对妊娠中EPC的研究进展综述。

关键词: 血管内皮祖细胞, 妊娠, 子痫前期, 妊娠期糖尿病

Abstract: Endothelial progenitor cells（EPC）are precursors of vascular endothelial cells （EC），which is mainly derived from the umbilical venous blood，adult peripheral blood and bone marrow．It plays an important part in the formulation of human embryonic vasculogenesis. Moreover, EPC gives consistent support to the growth of the vascular after birth. Pregnancy is a challenge to the maternal vascular system, requiring systemic adaptation and pronounced local adjustment in the uterus. Preeclampsia and gestational diabetes are mostly associated with endothelial dysfunction. This review summarizes our understanding of endothelial progenitor cells, with specific reference to their role in angiogenesis and human pregnancy.

Key words: Endothelial progenitor cell, Pregnancy, Preeclampsia, Gestational diabetes