国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (2): 125-128.

• 综述 • 上一篇    下一篇

环氧化酶信号通道与卵巢癌侵袭及转移

杨智宇,王海琳   

  1. 730000 兰州大学第一临床医学院(杨智宇)；甘肃省人民医院妇产科(王海琳)
  • 收稿日期:2009-07-31 修回日期:1900-01-01 出版日期:2010-04-15 发布日期:2010-04-15
  • 通讯作者: 王海琳

The Relevance Between COX-signaling Pathway and Ovarian Cancer Invasion as well as Metastasis

YANG Zhi-yu, WANG Hai-lin   

  1. School of First Clinical Medical, Lanzhou University, Lanzhou 730000, China （YANG Zhi-yu）; Gansu Province People Hospital, Lanzhou 730000, China （WANG Hai-lin）
  • Received:2009-07-31 Revised:1900-01-01 Published:2010-04-15 Online:2010-04-15
  • Contact: WANG Hai-lin

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摘要： 归纳上皮性肿瘤的发生发展及侵袭和转移研究中的关键问题，以及环氧化酶2 （COX-2）和锌指转录因子Snail蛋白在上皮性肿瘤的表达情况、调控环节。初步探讨COX信号通道［COX-前列腺素E（PGEs）依赖途径］在上皮性卵巢癌的侵袭转移中的意义。在卵巢癌发生发展过程中的COX-2高表达导致前列腺素E水平增高，上调锌指转录因子Snail蛋白表达，后者与E-钙粘蛋白（E-cadherin）启动子上的E-Box作用元件结合而抑制E-cadherin的转录。作为细胞黏附分子的E-cadherin表达下调，促进肿瘤细胞侵袭转移潜力。

关键词: 环氧化酶2, 卵巢癌, E-钙粘蛋白, Snail, 侵袭转移

Abstract:

Firstly，we sum up some key issues on the occurrence, the development, the invasion and the metastasis research of epithelial tumors, and the way of the expression of COX-2 and zinc finger transcription factor Snail protein in the development of epithelial tumors and its regulatory aspects. Then the paper preliminarily explores the signal significance of cyclooxygenase-signaling pathway（COX-PGEs-dependent pathway） in epithelial ovarian cancer invasion and metastasis: the high expression of COX-2 in the occurrence and development of ovarian cancer can lead to increased levels of prostaglandin E, consequently increasing the zinc-finger transcription factor Snail protein expression, while the binding of Snail protein and E-cadherin promoter effect on the E-Box element inhibits E-cadherin transcription, because E-cadherin reduction as a cell adhesion molecule may promote tumor cell invasion and metastasis potential. Lastly the paper reviews the COX-signal channels and invasive behavior of malignant tumor cells, the mechanism of influence, and the zinc-finger transcription factor Snail as the invasive and metastatic potential of ovarian cancer marker protein.

Key words: Cyclooxygenase 2, Ovarian cancer, E-cadherin, Snail, Invasion and metastasis