国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (6): 591-593.

• 论著 • 上一篇    下一篇

卵巢非特异性类固醇细胞瘤2例分析及文献复习

李晓红 , 朱 婷   

  1. 215600 江苏省张家港市第一人民医院(李晓红);复旦大学附属妇产科医院(朱婷)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-12-15 发布日期:2011-12-15

Ovarian Nonspecific Steroid Cell Tumors——Two Case Reports and Literature Review

LI Xiao-hong，ZHU Ting   

  1. The First People′s Hospital of Zhangjiagang，Zhangjiagang 215600，Jiangsu Province，China（LI Xiao-hong）；Women′ Hospital， Fudan University，Shanghai 200011，China（ZHU Ting）
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-12-15 Online:2011-12-15

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被引次数

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摘要： 目的：探讨卵巢非特异性类固醇细胞瘤的临床、病理学特点，以及诊断和治疗方法。方法：回顾性分析复旦大学附属妇产科医院2000—2010年间收治的2例卵巢非特异性类固醇细胞瘤患者的临床资料，并进行文献复习。结果：良、恶性卵巢非特异性类固醇细胞瘤各1例。2例患者均表现为闭经、男性化等特征，术中及病理所见均与已报道特点一致。良性患者经保守治疗后各项生化指标恢复正常，随访至今状况良好；而恶性患者虽经手术和化疗，10个月后仍死于肿瘤复发。结论：卵巢非特异性类固醇细胞瘤是罕见的卵巢肿瘤，治疗以手术为主，部分患者为恶性，可行化疗，但预后较差。

关键词: 卵巢肿瘤, 甾醇类, 免疫组织化学, 诊断, 鉴别, 病例报告

Abstract: Objective：To study the clinical，pathological manifestations，diagnostic and treatment methods of the ovarian nonspecific steroid cell tumors. Methods：The clinical data of patients diagnosed with ovarian nonspecific steroid cell tumors，during 2000—2010 were retrospective analyzed in our hospital. The relevant published articles were reviewed as well. Results：The two patients have been treated in our hospital during the period，one was benign and other was malignant. Both patients displayed with amenorrhea and masculine characteristics. Intraoperative and pathological findings are consistent with the descriptions of reported literatures. The benign patient was recovered uneventfully with conservative surgery and the biochemical parameters returned to normal level. The malignant one died 10 months after diagnosis with tumor recurrence despite aggressive surgery and postoperative adjuvant chemotherapy. Conclusions：Ovarian nonspecific steroid cell tumors，are rare ovarian tumor. Surgery should be preferred in treatment of such tumor. Some of the tumor was malignant and postoperative adjuvant chemotherapy should be added，while the prognosis is still very poor.

Key words: Ovarian neoplasms, Sterols, Immunohistochemistry, Diagnosis, differential, Case reports