国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (1): 45-47.

• 综述 • 上一篇    下一篇

Wnt/JNK通路中效应因子在妇科肿瘤中的作用


魏 恒 , 王诗卓,张淑兰   

  1. 110004 沈阳,中国医科大学附属盛京医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-02-15 发布日期:2012-02-15

The Effect Factor of Wnt/JNK Pathway in Gynecological Tumors

WEI Heng，WANG Shi-zhuo，ZHANG Shu-lan   

  1. Department of Obstetrics and Gynecology，the Shengjing Hospital of China Medical University，Shenyang 110004，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-02-15 Online:2012-02-15

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摘要： Wnt信号传导通路包括经典的Wnt信号传导途径，Wnt/Ca2+途径和Wnt/JNK信号通路。Wnt信号通路在真核生物中是高度保守且最重要的信号途径之一。其广泛存在于动物发育过程中，包括细胞增殖不同阶段，细胞分化，极性和迁移，并且与胚胎发生密切相关。Wnt/JNK信号通路又称为细胞平面极性途径，非经典的Wnt信号传导途径，通过重排细胞骨架来调控细胞极性。Wnt/JNK信号通路中效应因子在不同的肿瘤细胞中的表达不同。大量实验证明，Wnt/JNK通路中的效应因子通过此通路在肿瘤中的侵袭，调控肿瘤细胞凋亡以及肿瘤治疗方面发挥重要作用。近年展开的Wnt/JNK通路研究，主要集中在对果蝇和脊椎动物为模型的研究，探讨其在胚胎形成时的作用。近年来研究发现Wnt/JNK中效应因子与妇科肿瘤的关系密切，并在不同妇科肿瘤中发挥不同的作用。就Wnt/JNK通路的信号传导途径，在肿瘤细胞中的作用机制及其在妇科肿瘤中的作用做一综述。

关键词: 信号传导, 宫颈肿瘤, 卵巢肿瘤, 乳腺肿瘤, 子宫内膜肿瘤

Abstract: Wnt signaling pathway including：the classic Wnt signaling pathway，Wnt/Ca2+ pathway，Wnt/JNK signaling pathway. Wnt/JNK signaling pathway，also known as PCP pathway， non-classical Wnt signaling pathway，through the rearrangement of the cytoskeleton to regulate cell polarity，The effect of factors in Wnt / JNK signaling pathway express different role in different tumor cells. Experimental results demonstrate Wnt/JNK pathway in the effect factor through this pathway in tumor invasion，regulation of tumor cell apoptosis and playing an important role in cancer therapy. This article reviews literature about Wnt / JNK pathway in signal transduction pathway in the mechanism of tumor cells and its role in gynecological tumors.

Key words: Signal transduction, Uterine cervical neoplasms, Ovarian neoplasms, Breast neoplasms, Endometrial neoplasms