国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (2): 158-162.

• 综述 • 上一篇    下一篇

微小RNA与卵巢癌化疗耐药及预后

庄玉玉,万小平   

  1. 200030 上海交通大学附属国际和平妇幼保健院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-04-15 发布日期:2012-04-15
  • 通讯作者: 万小平

MicroRNA in Ovarian Cancer Drug Resistance and Prognosis

ZHUANG Yu-yu，WAN Xiao-ping   

  1. Department of Obstetrics and Gynecology，Shanghai Jiao Tong University Affiliated International Peace Maternity and Child Health Hospital，Shanghai 200030，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-04-15 Online:2012-04-15
  • Contact: WAN Xiao-ping

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摘要： 化疗耐药是导致晚期卵巢癌患者预后不良的主要原因。寻找卵巢癌化疗敏感性标记物是当前研究的热点。微小RNA（microRNA，miRNA）是一类非编码小分子RNA，可在转录后水平负性调控基因表达。新近大量研究表明卵巢癌中一些异常表达的miRNAs可调节药物敏感性相关基因的表达，导致肿瘤细胞对抗肿瘤药物的敏感性发生改变；以特定miRNAs为靶点的治疗可能通过克服抗药性而为卵巢癌的治疗开辟新的途径。提示miRNAs可能成为一种潜在的预后分层及个体化治疗的有效工具。就miRNAs在卵巢癌化疗耐药及预后判断中的研究进展进行综述。

关键词: 微RNAs, 基因表达调控, 卵巢肿瘤, 癌, 抗药性, 肿瘤, 预后

Abstract: Resistance to chemotherapy is a major cause that leads to poor prognosis in advanced ovarian cancer. Identification of chemosensitivity biomarkers for ovarian cancer has become a hotspot.MicroRNAs are small non-coding RNA molecules that can negatively regulate gene expression at the posttranscriptional level. A rapidly growing number of recent studies show that some aberrantly expressed miRNAs in ovarian cancer could target genes related to drug sensitivity，resulting in the altered sensitivity of cancer cells to anti-cancer drugs；the specific targeting of miRNAs could open new avenues for cancer treatment through overcoming drug resistance. These results suggest that miRNAs may be a potentially useful tool for prognostic stratification and individualized treatment.This review focused on the research progresses of miRNAs in ovarian cancer drug resistance and prognosis.

Key words: MicroRNAs, Gene expression regulation, Ovarian neoplasms, Carcinoma, Drug resistance, neoplasm