国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (1): 22-24.

• 综述 • 上一篇    下一篇

子宫内膜异位症与Foxp3关系的研究进展

钱诚，白延青   

  1. 315010 浙江省宁波市中医院（钱诚）；宁波大学医学院附属医院（白延青）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-02-15 发布日期:2014-02-15

Development in Research of Endometriosis and Foxp3

QIAN Cheng，BAI Yan-qing   

  1. Ningbo Municipal Hospital of TCM，Ningbo 315010，China（QIAN Cheng）；Affiliated Hospital of Ningbo University Medical College，Ningbo 315030，China（BAI Yan-qing）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-02-15 Online:2014-02-15

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摘要： 子宫内膜异位症是妇科常见良性疾病，主要引起盆腔痛和不孕，目前发病机制不明。近年来关于免疫缺陷与子宫内膜异位症发病之间的关系有不少研究。这其中，调节性T细胞在子宫内膜异位症发病中的作用日益受到重视。CD4+CD25+调节性T细胞是主动免疫抑制反应所必需的。转录因子Foxp3特异性表达于CD4+CD25+调节性T细胞，可作为调节性T细胞的一个特异性标志。Foxp3在CD4+CD25+调节性T细胞生长发育和发挥作用中起关键的调节作用。就转录因子Foxp3的表达与子宫内膜异位症发病之间的关系作综述。

关键词: 子宫内膜异位症, 转录因子, CD4阳性T淋巴细胞, T淋巴细胞, 不育, 女（雌）性, Foxp3

Abstract: Endometriosis is a common benign gynecologic disease, which causes pelvic pain and infertility, but the pathogenesis is unknown at present. CD4+CD25+ regulatory T cells are essential for the active suppression of autoimmunity.Transcription factors Foxp3 expression on CD4+CD25+ regulatory T cells specifically, which can be used as a specific symbol of regulatory T cells. Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function. The role of regulatory T cells in endometriosis has been paid attention to. In this review，we focus on the relevance between the expression of Foxp3 and the pathogeny of endometriosis.

Key words: Endometriosis, Transcription factors, CD4-positive T-lymphocytes, T-lymphocytes, Infertility, female