国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (3): 229-231.

• 综述 • 上一篇    下一篇

MicroRNA-375在妇科恶性肿瘤中的研究进展

张利利，郝敏，赵卫红   

  1. 030001 太原，山西医科大学第二医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-06-15 发布日期:2014-06-15
  • 通讯作者: 郝敏

Research Progress of MicroRNA-375 in Gynecological Malignant Tumors

ZHANG Li-li，HAO Min，ZHAO Wei-hong   

  1. The Second Hospital of Shanxi Medical University，Taiyuan 030001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-06-15 Online:2014-06-15
  • Contact: HAO Min

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摘要： 微小RNA-375（microRNA-375，miR-375）属于高度保守的miRNAs家族，可通过调节一系列靶基因的表达，在抑制细胞增殖、促进细胞凋亡、抑制侵袭转移等方面发挥重要的抑癌作用。研究发现，miR-375在多种恶性肿瘤细胞系及实体组织中均呈低表达，且与肿瘤的发生发展密切相关，尤其近年miR-375在宫颈癌和子宫内膜癌中作用的研究日益增多，但其相关机制仍有待进一步研究。针对miR-375的生物学功能及其在妇科恶性肿瘤中的研究进展进行综述。

关键词: 微RNAs, 肿瘤, 宫颈肿瘤, 子宫内膜肿瘤, 细胞增殖, 细胞凋亡

Abstract: MicroRNA-375 is a highly conservative miRNA，which play important roles in suppressing proliferation，promoting apoptosis，suppressing invasion and metastasis by means of regulating the expression of genes. The research has revealed that miR-375 is remarkably down-regulated in many tumor cells and ontic tissues，and is closely related in cancer development and progression. Recent years，the research on miR-375 in cervical cancer and endometrial cancer is increasing，but the mechanism should be studied future. This article elaborates biological function of miR-375 and improvements of some studies in gynecological malignant tumors.

Key words: MicroRNAs, Neoplasms, Uterine cervical neoplasms, Endometrial neoplasms, Cell proliferation, Apoptosis