国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (2): 158-160.

• 综述 • 上一篇    下一篇

叶酸受体α在妇科恶性肿瘤中的研究进展

陈亮亮，郝敏   

  1. 030001 太原，山西医科大学第二医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-04-15 发布日期:2015-04-15
  • 通讯作者: 郝敏

Research Progress of the Folate Receptor Alpha in Gynecological Malignant Tumor

CHEN Liang-liang，HAO Min   

  1. The Second Hospital of Shanxi Medical University，Taiyuan 030001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-04-15 Online:2015-04-15
  • Contact: HAO Min

PDF (PC)

5507

摘要： 叶酸受体（folate receptor，FR）是一种糖基磷脂酰肌醇偶联蛋白，包括FRα、FRβ、FRγ三种，其中FRα在正常组织中低表达，在肿瘤细胞膜表面高表达，参与肿瘤的发生与发展。近年研究表明，FRα多表达于腺癌，如卵巢癌、子宫内膜癌、宫颈腺癌，非小细胞肺癌和恶性间皮瘤等。已有研究显示，FRα通过参与叶酸代谢、雌激素受体调控及细胞外信号调节激酶（ERK）信号通路等多种途径影响肿瘤的发生、发展。有关FRα在妇科肿瘤组织中的表达研究仍存在许多争议，且具体作用机制尚不明确。针对FRα在妇科肿瘤中的表达及其可能机制进行综述。

关键词: 叶酸, 生殖器肿瘤, 女（雌）性, 信号传导, 治疗, 叶酸受体α

Abstract: The folate receptor（FR） is a glycosylphosphatidylinositol linked protein, including FRα, FRβ, FRγ. Its expression is low in normal tissue except for higher in human tumor cell membrane surface in the development of tumor. In recent years, studies have shown that FRα has more expression in adenocarcinoma, such as ovarian cancer, endometrial cancer, cervical adenocarcinoma, non-small-cell lung cancer and malignant mesothelioma. Researches have shown that FRα affects the occurrence and development of tumor by participating in folic acid metabolism and estrogen receptor regulation and ERK signaling pathway. FRα expression in the gynecologic tumor is still controversial, and the specific mechanism is unknown. The study of various mechanisms of FR will be helpful in the early diagnosis and treatment of gynecological tumor.

Key words: Folic acid, Genital neoplasms, female, Signal transduction, Therapy, Folate receptor alpha