关键词: 双胎疾病, 妊娠, 先天畸形

Abstract: Objective：To investigate the clinical analysis from 70 cases with malformations in the fetuses of twin pregnancy from 2011 to 2013 at Shenzhen Maternal and Child Healthcare Hospital． Methods：Describe the clinical characteristics of 70 twin pregnancies complicated with fetal malformations. According to the way of conception and the type of chorionic，these twin pregnancies were divided into natural conception and artificial insemination group, monochorionic and dichorionic group respectively, and were compared the pregnancy outcomes and the main clinical characteristics by different groups. Results：65.71% of pregnant women were equal or greater than 30 years old, and 64.29% are monochorionic twins. Ｐｒｅｇｎａｎｃｙ ｃｏｍｐｌｉｃａｔｉｏｎｓ ｗｅｒｅ ｒｅｍａｒｋａｂｌｙ ｈｉｇｈｅｒ（９１．４２％）， ｔｈｅ ｔｏｐ ｆｉｖｅ ｃｏｍｐｌｉｃａｔｉｏｎｓ ｗｅｒｅ ｐｒｅｔｅｒｍ ｌａｂｏｒ， ｗｅａｋｎｅｓｓ ｏｆ ｃｏｎｔｒａｃｔｉｏｎｓ， ｐｌａｃｅｎｔａｌ ａｂｎｏｒｍａｌｉｔｙ， ｓｅｌｅｃｔｉｖｅ ｇｒｏｗｔｈ ｒｅｓｔｒｉｃｔｉｏｎ， ｈｙｐｅｒｔｅｎｓｉｖｅ ｄｉｓｏｒｄｅｒｓ ｉｎ ｐｒｅｇｎａｎｃｙ． Ｏｎｅ ｆｅｔｕｓ ａｆｆｅｃｔｅｄ ｗａｓ ８９．３３％， ｔｈｅ ｔｏｐ ｆｉｖｅ ａｂｎｏｒｍａｌｉｔｉｅｓ ｗｅｒｅ ｃａｒｄｉｏｖａｓｃｕｌａｒ ｓｙｓｔｅｍ, musculoskeletal system, urogenital system, cleft lip and palate and nervous system. Conclusions：Twin pregnancies complicated with fetal malformations are above 30 years old, and have higher incidence of complications. One fetus affected is more common than both fetuses affected; single defect is more common than multiple defects. A single system malformation is more common than multiple system malformation. The cardiovascular system malformation is the most common malformation in twin fetuses, musculoskeletal system is the second and the urogenital system malformation ranks the third. Especially in ventricular septal defect in cardiovascular malformation. So, for over 30 years old pregnant women with twins and pregnant complications, we must strengthen antenatal fetal malformation screening, and especially should focus on screening cardiovascular system, bone of limbs, urogenital system malformation.

Key words: Diseases in twins, Pregnancy, Congenital abnormalities