国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (4): 365-368.

• 综述 •    下一篇

血清尿酸水平与妊娠期高血压疾病的关系

陈继明，高红艳，汪云，陈大立，柴利强   

  1. 213003 江苏省常州市，苏州大学附属第三医院妇产科（陈继明，高红艳）；南京医科大学附属苏州医院妇产科（陈继明，汪云，陈大立，柴利强）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 柴利强

The Relationship between Serum Uric Acid Level and Hypertensive Disorder Complicating Pregnancy

CHEN Ji-ming，GAO Hong-yan，WANG Yun，CHEN Da-li，CHAI Li-qiang   

  1. Department of Obstetrics and Gynecology， The Third Affiliated Hospital of Suzhou University，Changzhou 213003，Jiangsu Province，China（CHEN Ji-ming，GAO Hong-yan）；Department of Obstetrics and Gynecology，Suzhou Hospital Affiliated to Nanjing Medical University，Suzhou 215002，Jiangsu Province，China（CHEN Ji-ming，WANG Yun，CHEN Da-li，CHAI Li-qiang）
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-08-15 Online:2015-08-15
  • Contact: CHAI Li-qiang

PDF (PC)

5404

摘要： 妊娠期高血压疾病（HDCP）是一种较为常见的严重危害母婴健康的妊娠期特有疾病，其病因及发病机制尚不明确。HDCP主要病理生理是全身小动脉痉挛，内皮损伤和局部缺血。血清尿酸（UA）是人类嘌呤代谢的最终产物，主要由肾脏排泄。研究证实，HDCP与血清UA关系密切，且两者相互作用、相互影响。监测血清UA对于评估HDCP尤其是子痫前期的发生与发展可能具有重要意义。但临床上应用血清UA水平预测或早期诊断子痫前期仍存在争议；联合多种检测指标，构建新的检测模型，是否可有效提高预测价值，目前尚未明确。主要围绕HDCP的基本病理生理与血清UA代谢的相互影响，血清UA与子痫前期发病的密切关系，血清UA对子痫前期临床诊断、母儿预后的预测价值等方面进行综述。

关键词: 尿酸, 高血压, 妊娠性, 先兆子痫, 诊断, 预测

Abstract: Hypertensive disorders complicating pregnancy （HDCP） is a common clinical disease specially correlated to pregnancy，which had serious harm on maternal and child health. The etiology and pathogenesis mechanism of HDCP is not yet entirely clear. The main pathophysiological change of HDCP is systemic small vessel spasm，endothelial injury and local ischemia. Serum uric acid （UA） is the end product of purine metabolism in human，which is mainly excreted by kidney. Previous studies confirmed that the relationship between HDCP and serum UA was extremely close，and they had both interaction and influence to each other. It might have an important significance to monitor serum UA level for assessment of the occurrence and development of HDCP，especially preeclampsia. However，there is still no small controversy on the clinical application of serum UA level for the prediction or early diagnosis of preeclampsia. It is not clear whether the predictive value could be effectively improved by combination with a variety of detection indexes and construction of a new detection model. A summarization will be established in this paper on the issues as follows： the basic pathophysiology of HDCP，and the interaction between HDCP and serum UA metabolism. The close relationship between serum UA and the pathogenesis of preeclampsia. The predictive value of serum UA on the clinical diagnosis along with the prognosis of mother and fetus in preeclampsia.

Key words: Uric acid, Hypertension, pregnancy-induced, Pre-eclampsia, Diagnosis, Forecasting