国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (6): 605-607.

• 综述 •    下一篇

卵巢癌肿瘤干细胞的研究进展

吴泉锋，汪希鹏   

  1. 200040 上海市第一妇婴保健院妇科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-12-15 发布日期:2015-12-15
  • 通讯作者: 汪希鹏

Advances in Ovarian Cancer Stem Cells

WU Quan-feng，WANG Xi-peng   

  1. Department of Gynecology，Shanghai First Maternity and Infant Hospital，Shanghai 200040，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-12-15 Online:2015-12-15
  • Contact: WANG Xi-peng

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摘要： 肿瘤干细胞是存在于肿瘤组织中的一小群具有干细胞特性的细胞，具有自我更新、多分化潜能、高增殖能力和耐药性4个特点。卵巢癌是病死率最高、预后最差的妇科恶性肿瘤。由于部分卵巢癌细胞亚群具有干细胞特性，肿瘤较易产生化疗耐药性。很多研究表明肿瘤干细胞亚群存在于小鼠快速生长的肿瘤细胞中，并具有多向分化能力及耐药性。因此，深入了解肿瘤干细胞的生物学特性、表面标记以及如何靶向定位，对肿瘤干细胞的治疗具有重要临床意义。就卵巢癌干细胞的研究和临床应用进行综述。

关键词: 卵巢肿瘤, 癌, 肿瘤干细胞, 标记物, 生物学, 抗药性, 肿瘤

Abstract: Cancer stem cells(CSC) are a small group of cells with stem cell properties that are located in the tumor tissue. Ovarian cancer stem cells have four main features include self-renewing，multi-differentiating potential, strong proliferative ability and chemoresistance. Ovarian cancer has the highest mortality rate and poorest prognosis in gynecological malignant tumors. It has been considered, subset of cancer cells has acquired stem cell properties which causes the development of resistance to chemotherapeutic. Many studies show that there are subsets of cancer stem cells in fast-growing tumor cells in mice and these cells have various abilities of differentiation and resistance to chemotherapeutic. Thus, it plays an important role for therapy that gaining insight into the biological characteristics, surface markers of cancer stem cells and how to target in the treat of cancer stem cells. This review will highlight the research and clinical application of the ovarian cancer stem cells.

Key words: Ovarian neoplasms, Carcinoma, Neoplastic stem cells, Tumor markers, biological, Drug resistance