国际妇产科学杂志

国际妇产科学杂志 ›› 2018, Vol. 45 ›› Issue (6): 672-676.

• 论著 • 上一篇    下一篇

盆炎清栓联合头孢克洛治疗慢性盆腔炎的临床疗效评价

鲍天宇，杜梦君   

  1. 214002  江苏无锡，南京医科大学附属无锡妇幼保健院药学部
  • 收稿日期:2018-02-24 修回日期:2018-09-24 出版日期:2018-12-15 发布日期:2018-12-15
  • 通讯作者: 杜梦君，E-mail：ttfyuvb@163.com E-mail:wlkjxs@163.com

Effect of Penyanqing Suppository Combined with Cefaclor on Chronic Pelvic Inflammatory

BAO Tian-yu，DU Meng-jun   

  1. Department of Pharmacy，Wuxi Maternal and Child Care Hospital Affiliated to Nanjing Medical University，Wuxi 214002，Jiangsu Province，China
  • Received:2018-02-24 Revised:2018-09-24 Published:2018-12-15 Online:2018-12-15
  • Contact: DU Meng-jun，E-mail：ttfyuvb@163.com E-mail:wlkjxs@163.com

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摘要： 目的：探讨盆炎清栓联合头孢克洛对慢性盆腔炎的血清单核细胞趋化蛋白1（monocyte chemotactic protein 1，MCP-1）及T细胞亚群的影响。方法：选择2016年1月—2017年8月在南京医科大学附属无锡妇幼保健院诊治的慢性盆腔炎患者110例，按随机数字表法分为观察组和对照组，各55例。对照组予头孢克洛治疗，观察组予盆炎清栓联合头孢克洛治疗，治疗2个疗程后观察2组患者的疗效、血液流变学、子宫动脉血流、血清MCP-1及T淋巴细胞亚群的情况。结果：观察组的总有效率为92.73%，显著高于对照组（74.55%），差异有统计学意义（P＜0.05）。治疗前2组患者的血液流变学指标、子宫动脉血流灌注指数（perfusion index，PI）和阻力指数（resistent index，RI）、血清MCP-1、T细胞亚群差异无统计学意义（P＞0.05）；治疗后2组患者血小板聚集率、红细胞压积、全血比黏度、纤维蛋白原和子宫动脉血流PI较治疗前均下降，且观察组较对照组降低更为显著，差异有统计学意义（P＜0.05）。治疗后2组患者的MCP-1均降低，且观察组较对照组降低更为显著，差异有统计学意义（P＜0.05）。治疗后2组患者的CD4+均升高，观察组升高更加显著；2组患者的CD8+均下降，观察组降低更加显著；2组患者CD4+/CD8+比值均升高，观察组升高较对照组显著，差异均有统计学意义（P＜0.05）。结论：盆炎清栓联合头孢克洛治疗慢性盆腔炎的疗效较好，可有效地改善血液流变学，降低血清MCP-1水平，改善T淋巴细胞亚群，在临床上可广泛使用。

关键词: 盆炎清栓, 头孢克洛, 慢性盆腔炎, 血清MCP-1, T淋巴细胞亚群

Abstract: Objective：To investigate the effects of Penyanqing suppository combined with cefaclor on serum monocyte chemotactic protein-1 (MCP-1) and T cell subsets in patients with chronic pelvic inflammation. Methods: 110 patients with chronic pelvic inflammatory disease, who were diagnosed and treated in our hospital from January 2016 to August 2017, were randomly divided into observation group and control group with 55 cases in each group. The control group was treated with cefaclor, while the observation group received penyanqing suppository combined with cefaclor. After 2 courses of treatment, the curative effect, hemorheology, uterine artery blood flow, serum MCP-1 and T lymphocyte subsets were observed in the two groups. Results: The total effective rate of observation group was 92.73%, which was significantly higher than that of the control group (74.55%) (P＜0.05). There were no significant differences in hemorheology, uterine artery perfusion index (PI), resistance index (RI), serum MCP-1 and T cell subsets between the two groups before treatment (P＞0.05). After treatment, hematocrit, platelet aggregation rate, blood viscosity, fibrinogen, uterine artery blood flow PI in two groups were significantly decreased,  observation group decreased significantly compared with the control group, the difference was significant (P＜0.05). After treatment, the MCP-1 of the two groups decreased significantly, and observation group was lower than control group, and the difference was statistically significant (P＜0.05). After treatment, the CD4+ of the two groups increased, the observation group increased more than control group, the CD8+ of the two groups decreased, the observation group decreased significantly, the CD4+/CD8+ level of the observation group was  higher than  control group, the difference was significant (P＜0.05). Conclusions: Penyanqing suppository combined with cefaclor is effective in treating chronic pelvic inflammatory disease. It can improve hemorheology effectively, reduce the level of serum MCP-1, T lymphocyte subsets, which can be widely used in clinic.

Key words:  Penyanqing suppository, Cefaclor, Chronic pelvic inflammatory disease, Serum MCP-1, T lymphocyte subsets