关键词: 雄激素类, 多囊卵巢综合征, 流产, 自然, 治疗

Abstract: Androgens play a vital role in maintaining the health of the female reproductive system. Either excessive or deficient androgens may result in the occurrence of female reproductive endocrine diseases. Hyperandrogenism is one of the important characteristics and pathogenic factors of polycystic ovary syndrome (PCOS). Hyperandrogenism may play its pathogenic role in women with PCOS by influencing epigenetic modification, hypothalamic neuroendocrine, follicular development, ovarian function and metabolism. The mechanism of androgens action in recurrent spontaneous abortion mainly affects endometrial receptivity and embryo implantation. Women with premature ovarian insufficiency often have low testosterone levels. Androgen deficiency may be associated with granulosa cells apoptosis and diminished ovarian reserve. The treatment of androgen reduction is an important part of the clinical treatment of PCOS, while androgen supplements can be used in women with low function ovarian reserve, whereas further studies are needed due to the lack of long-term safety and efficacy.

Key words: Androgens, Polycystic ovary syndrome, Abortion, spontaneous, Therapy