国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (6): 603-605.

• 综述 • 上一篇    下一篇

二甲双胍在合并代谢综合征的子宫内膜样腺癌中的作用及机制

倪镌，寿华锋，楼寒梅   

  1. 310022 杭州，浙江省肿瘤医院妇瘤科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-12-15 发布日期:2014-12-15
  • 通讯作者: 楼寒梅

Effect and Mechanism of Metformin in Endometrial Adenocarcinoma Patients with Metabolic Syndrome

NI Juan，SHOU Hua-feng，LOU Han-mei   

  1. Department of Gynecology Oncology，Zhejiang Cancer Hospital，Hangzhou 310022，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-12-15 Online:2014-12-15
  • Contact: LOU Han-mei

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摘要： 二甲双胍作为一线降糖药物，在糖尿病治疗领域发挥重要作用。代谢综合征（MS）是多种代谢物异常集结的病理状态，与其有关的远期不良结局日益受到关注。研究发现，MS各环节与子宫内膜样腺癌发病机制关系密切，两者可能存在共同的病理生理基础——胰岛素抵抗。二甲双胍具有抑制胰岛素抵抗、调节细胞因子水平及独特的抗肿瘤干细胞功能，可能发挥重要的负性调节作用，并可能成为MS人群预防及治疗子宫内膜样腺癌的新型药物。

关键词: 二甲双胍, 代谢综合征X, 子宫内膜肿瘤, 治疗

Abstract: Metformin as the first-line drugs, play an important role in the treatment of diabetes. Metabolic syndrome（MS） is a pathological condition of abnormal aggregation of multiple metabolite resulting. The long-term adverse outcomes were payed more and more attention by people. The study found, MS is recognized risk factor of endometrial adenocarcinoma, there may be a common pathophysiological basis of insulin resistance. Metformin reduces insulin resistance, regulates the level of cytokines and exerts anti-tumor stem cell function, it is a potent inhibitor of metabolic syndrome and endometrial adenocarcinoma.

Key words: Metformin, Metabolic syndrome X, Endometrial neoplasms, Therapy