Abstract: Cervical cancer is the most common tumor in gynecologic oncology，and the generation and progression of tumor is always associated with immunosuppression. In tumour immunity，T cell-mediated immune response plays a key role. The second signal pathway in T cell activation requires the combination of costimulatory and its receptors. Lacking of the second signal of costimulatory, antigen complexes formed in the first signal pathway can lead to inactivation or dysfunction of T cells. In recent years, B7 family has become an intense focus of research in costimulatory molecules，and can play a positive and/or negative regulatory role in T cell-mediated immune response. This paper is aimed to review the expression and significance of negative costimulatory molecule B7-H4 in the blood and tissues of patients with cervical cancer, and to discuss the problems in the study of cervical cancer, and to introduce briefly the expression and significance in ovarian cancer，as well as to prospect the prognosis，the help of auxiliary diagnosis and immunization therapy. Also it is aimed to further clarify the mechanism of immunosuppression of cervical cancer，and further explore the effective methods of immune targeted treatment.