国际妇产科学杂志

国际妇产科学杂志 ›› 2017, Vol. 44 ›› Issue (2): 129-132.

• 综述 • 上一篇    下一篇

间充质干细胞与卵巢癌的相互作用

高彤，姜伟   

  1. 200090  上海，复旦大学附属妇产科医院妇科
  • 收稿日期:2016-12-22 修回日期:2017-02-01 出版日期:2017-04-15 发布日期:2017-05-18
  • 通讯作者: 姜伟，E-mail：jw52317@126.com E-mail:jw52317@126.com

The Interaction between Mesenchymal Stem Cells and Ovarian Cancer.

GAO Tong，JIANG Wei   

  1. Department of Gynecology，Obstetrics and Gynecology Hospital of Fudan University，Shanghai 200090，China
  • Received:2016-12-22 Revised:2017-02-01 Published:2017-04-15 Online:2017-05-18

PDF (PC)

6980

摘要： 间充质干细胞（mesenchymal stem cell，MSCs）与肿瘤的关系日益受到重视。MSCs可趋化到肿瘤局部，参与间质形成，与肿瘤细胞相互作用。研究表明，MSCs可通过分泌细胞因子、促进肿瘤干细胞化等抑制或促进卵巢癌细胞增殖；与卵巢癌细胞发生交互作用，促进或抑制卵巢癌的侵袭和转移；MSCs还可通过磷脂酰肌醇-3激酶/丝氨酸苏氨酸激酶（PI3K/AKT）、骨形态发生蛋白4/Hedgehog（BMP4/HH）信号通路增强卵巢癌化疗耐药性；可利用MSCs对肿瘤组织的趋向性将其作为载体构建靶向给药系统对卵巢癌进行靶向治疗。因此，MSCs在卵巢癌的发生发展中起重要作用，为该病的治疗提供了新的研究思路，但具体作用及机制仍存在较多争议，有待进一步研究。本文就MSCs及经修饰的MSCs与肿瘤细胞相互作用对卵巢癌的增殖、转移及化疗耐药等的影响及其机制作一综述，旨在为卵巢癌的治疗提供新思路。V

关键词: 卵巢肿瘤, 间质干细胞, 细胞增殖, 肿瘤侵袭, 肿瘤转移

Abstract: Mesenchymal stem cells (MSCs) can be chemotaxis to tumor site, participate in the formation of stroma and interact with tumor cells. According to different reports, MSCs can promote ovarian cancer cells proliferation by secreting cytokines and promote tumor stem cells differentiation;different types of MSCs can interact with ovarian cancer cells and promote or inhibit the invasion and metastasis of ovarian cancer; MSCs can promote the chemotherapeutic drug resistance of ovarian cancer by activating PI3K/Akt and BMP4/HH signaling pathways; MSCs can also be used as carriers to construct a targeted drug delivery system. These results indicate that MSCs play an important role in ovarian cancer and give us new research ideas, but the specific role and mechanism is still controversial and further studies are needed. Here, we reviewed the effects and mechanisms of MSCs or modified MSCs on the growth, metastasis and chemo-resistance of ovarian cancer,our purpose is to explore new ideas for ovarian cancer treatment.

Key words: Ovarian neoplasms, Mesenchymal stem cells, Cell proliferation, Tumor invasion, Tumor metastasis