国际妇产科学杂志

国际妇产科学杂志 ›› 2018, Vol. 45 ›› Issue (1): 23-27.

• 综述 • 上一篇    下一篇

瘦素与子宫内膜容受性相关研究进展

央茂，王雪彤，潘楚乔，唐欣悦，高秀秀，丁之德   

  1. 200025上海交通大学医学院临床医学系2015级临床八年制（央茂，王雪彤，潘楚乔，唐欣悦），组织胚胎学与遗传发育学系（高秀秀，丁之德）
  • 收稿日期:2017-09-18 修回日期:2017-11-30 出版日期:2018-02-15 发布日期:2018-02-15
  • 通讯作者: 丁之德，E-mail：zding@shsmu.edu.cn E-mail:zding@shsmu.edu.cn
  • 基金资助:
    上海交通大学医学院第十一期大学生科学创新项目（1117079）；上海交通大学基础医学院第十一期RBL项目（2017001）

The Research Advances in the Relationship between Leptin and Endometrial Receptivity

YANG Mao, WANG Xue-tong, PAN Chu-qiao, TANG Xin-yue, GAO Xiu-xiu, DING Zhi-de   

  1. Department of clinical medicine, Grade 2015（ＹANG Mao, WANG Xue-tong, PAN Chu-qiao, TANG Xin-yuｅ）, Department of Histology, Embryology, Genetics and Developmental Biology（ＧAO Xiu-xiu, DING Zhi-de）, School of Medcine, Shanghai Jiao Tong University, Shanghai 200025, China
  • Received:2017-09-18 Revised:2017-11-30 Published:2018-02-15 Online:2018-02-15
  • Contact: DING Zhi-de, E-maｉｌ： zding@shsmu.edu.cn E-mail:zding@shsmu.edu.cn

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摘要： 近年来，随着辅助生殖技术的发展而获得的优质胚胎数量日趋增多，但胚胎着床率始终未能达到较高的水平。因此，良好的子宫内膜容受性成为胚胎成功着床的关键一环。瘦素作为一种常见的脂肪因子，可通过与靶细胞膜上的瘦素受体结合，激活下游信号通路并合成转录因子后，与特定基因启动子区域的DNA元件相互作用，启动目的基因转录，从而发挥重要的生物学功能。瘦素已被广泛证实对人体的生殖功能有重要影响，特别是瘦素会影响与胚胎着床有关的生殖调控因子表达水平、母体内分泌和代谢状况及子宫内膜微环境等。更有研究发现，瘦素及其受体在人类和啮齿动物的子宫内膜上均有较高水平的表达，因此认为其直接或间接地影响子宫内膜容受性。现就瘦素与子宫内膜容受性的相关研究进展进行综述，尝试为临床对子宫内膜容受性的评估提供一个崭新的分子标志物。

关键词: 瘦素, 受体, 瘦素, 细胞因子类, 子宫内膜, 子宫内膜容受性

Abstract: In recent years, an increasing number of high-quality embryos are obtained accompanied by the development of assisted reproductive technology. However, the embryo implantation rate still remains unsatisfactory in the clinic. Therefore, endometrial receptivity becomes a key step for the successful embryo implantation. Leptin, a common adipokine, activates downstream signaling pathways and synthesizes transcription factors by binding to leptin receptors on target cell membranes, then interacts with DNA elements in the promoter region of specific genes to initiate transcription, plays an important biological role. It has been widely proven that leptin is significantly influencial in human reproductive function. In particular, leptin affects the expression of reproductive regulatory factors associated with embryo implantation, maternal endocrine and metabolic status, and endometrial microenvironment. Furthermore, more recent researches documented that both leptin and leptin receptor were high expressions on the endometrium in both human and rodents. Thus, it is considerable that leptin has taken an effect on the endometrial receptivity directly or indirectly. This review summarizes the research advances in relationship between leptin and endometrial receptivity in order to provide a new biomarker for the evaluation of endometrial receptivity clinically.

Key words: Leptin, Receptors, leptin, Cytokines, Endometrium, Endometrial receptivity