线粒体在子宫内膜癌中的作用及治疗

doi:10.12280/gjfckx.20240245

摘要/Abstract

摘要：

线粒体是一种广泛存在于哺乳动物细胞中的动态、半自主细胞器，在维持正常子宫内膜细胞稳态中起着重要作用。子宫内膜癌是女性常见的恶性肿瘤，其发病年龄呈现年轻化趋势，因此提高治疗子宫内膜癌的能力对改善其预后有重要意义。近年的研究表明，线粒体生物合成过程异常、线粒体动力学失调、线粒体功能障碍与子宫内膜癌的发生发展密切相关。在子宫内膜癌治疗方面，线粒体也展现出巨大的潜力，如诱导细胞凋亡和靶向线粒体相关的子宫内膜癌干细胞的治疗等。深入理解线粒体在子宫内膜癌发病机制中的作用，将为子宫内膜癌的治疗提供新的视角。

关键词: 线粒体, 子宫内膜肿瘤, DNA, 线粒体, 线粒体动力学, 调节细胞死亡, 线粒体生物合成

Abstract:

Mitochondria are dynamic, semi-autonomous organelles widely found in mammalian cells and play an important role in maintaining normal endometrial cell homeostasis. Endometrial carcinoma is a common malignant tumor in women, and its age of onset is showing a trend towards younger age, so improving the ability to treat endometrial carcinoma is important to improve its prognosis. Recent studies have shown that abnormal mitochondrial biosynthesis process, dysregulation of mitochondrial dynamics, and mitochondrial dysfunction are closely related to the occurrence and development of endometrial carcinoma. Mitochondria also show great potential in endometrial carcinoma treatment, such as induction of apoptosis and targeting of mitochondria-associated endometrial carcinoma stem cells.Deeply understanding of the role of mitochondria in the pathogenesis of endometrial carcinoma will provide new perspectives for endometrial carcinoma treatment.

Key words: Mitochondria, Endometrial neoplasms, DNA, mitochondrial, Mitochondrial dynamics, Regulated cell death, Mitochondrial biosynthesis

张益田, 李小丽. 线粒体在子宫内膜癌中的作用及治疗[J]. 国际妇产科学杂志, 2024, 51(4): 375-379.

ZHANG Yi-tian, LI Xiao-li. The Role and Treatment of Mitochondria in Endometrial Carcinoma[J]. Journal of International Obstetrics and Gynecology, 2024, 51(4): 375-379.

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