关键词: 子宫内膜肿瘤, 普查, 诊断筛查项目, 癌症早期检测, 基因组学, 表观基因组学, 生育力保护

Abstract:

Endometrial cancer is one of the three major gynecological cancers, and the proportion of endometrial cancer among women of childbearing age is increasing yearly. How to achieve effective, safe and economical prevention and control of endometrial cancer through early diagnosis and screening has become a major topic. At present, there are still huge challenges in the early diagnosis and screening of endometrial cancer, including inadequate methods and programs, uncertain screening objects, and lack of efficient and minimally or non-invasive methods. In recent years, the molecular and imaging protocols are gradually alleviating these difficulties, which are expected to become efficient and safe screening programs for endometrial cancer. This article is aimed to review the current status of endometrial cancer screening and the research progress of emerging molecular and imaging regimens of early screening and diagnosis of endometrial cancer, and explore the implementation of future screening strategies.

Key words: Endometrial neoplasms, Mass screening, Diagnostic screening programs, Early detection of cancer, Genomics, Epigenomics, Fertility preservation