Vimentin在常见妇科恶性肿瘤中的研究进展

doi:10.12280/gjfckx.20230615

摘要/Abstract

摘要：

波形蛋白（Vimentin）是一种重要的Ⅲ型中间丝蛋白，主要来源于间叶细胞。Vimentin在多种类型肿瘤中表达，其表达上调与肿瘤细胞迁移和侵袭能力有关，提示患者预后较差。Vimentin是肿瘤细胞上皮-间质转化的典型标志物，是潜在的药物靶点。研究表明，Vimentin在宫颈癌、卵巢癌和子宫内膜癌中均异常表达，且与患者的预后、转移和复发有关，具有潜在的临床应用价值。综述Vimentin与妇科恶性肿瘤的关系及可能机制。

关键词: 波形蛋白, 宫颈肿瘤, 卵巢肿瘤, 子宫内膜肿瘤, 预后

Abstract:

Vimentin is an important type Ⅲ intermediate filament protein, mainly derived from mesenchymal cells. Vimentin is expressed in various types of tumors, and up-regulated expression of Vimentin is related to the migration and invasion ability of tumor cells, suggesting poor prognosis. Vimentin is a typical marker of epithelial-mesenchymal transition of tumor cells and a potential drug target. Studies have shown that Vimentin is abnormally expressed in cervical cancer, ovarian cancer and endometrial cancer, and is related to prognosis, tumormetastasis and recurrence, which has potential clinical application value. This article reviews the relationship between Vimentin as well as gynecological malignancy and its possible mechanism.

Key words: Vimentin, Uterine cervical neoplasms, Ovarian neoplasms, Endometrial neoplasms, Prognosis

武霞, 晋雨楠, 范裕裕, 索玉平. Vimentin在常见妇科恶性肿瘤中的研究进展[J]. 国际妇产科学杂志, 2023, 50(6): 655-659.

WU Xia, JIN Yu-nan, FAN Yu-yu, SUO Yu-ping. Research Progress of Vimentin in Common Gynecological Malignancies[J]. Journal of International Obstetrics and Gynecology, 2023, 50(6): 655-659.

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