关键词:  卵巢肿瘤, 微RNAs, 肿瘤侵润, 肿瘤转移

Abstract: MicroRNA(miRNA) is a class of non-coding RNA molecule, 20-22 nucleotides in length, which affects the differentiation, proliferation, metastasis and necrosis of tumor cells by regulating target gene. It is fully reported that miRNA has a relationship with human malignant tumors and it has an abnormal expression in ovarian cancer. Ovarian cancer is one of the most common gynecologic malignant tumors, 90% of which are epithelial cancers, whose five-year survival rate is only 30%. Without obvious symptoms in early stage, it has a high metastatic rate when diagnosed. Many substances and pathways are involved in the mechanism of ovarian cancer invasion and metastasis. A large number of studies suggest that cancer stem cells related miRNA, epithelial-mesenchymal transition related miRNA, extracellular matrix related miRNA and angiogenesis related miRNA are relevant to invasion and metastasis of ovarian cancer. The abnormal expression of them are involved in invasion and metastasis of ovarian cancer by regulating the expression of downstream substance. In this article, we focus on the mechanism of miRNA in ovarian cancer invasion and metastasis.

Key words: Ovarian neoplasms, MicroRNAs, Neoplasm invasiveness, Neoplasm metastasis