SOCS1与外泌体微小RNA在子痫前期发病机制中的作用

doi:10.12280/gjfckx.20240757

摘要/Abstract

摘要：

子痫前期（preeclampsia，PE）是一种严重的妊娠期并发症，其主要症状包括高血压和多系统器官损害，严重影响母儿健康。终止妊娠是目前治疗PE的首选方法。尽管PE的发病机制尚未完全明确，但近年研究表明，不同来源的外泌体（exosomes）及其携带的微小RNA（microRNA，miRNA）在PE的发展中发挥关键作用，尤其是miRNA作为外泌体小RNA中最具代表性的一种，可通过调节滋养细胞功能和信号通路参与PE的病理生理过程。特别是，外泌体miRNA能够抑制细胞因子信号传导抑制因子1（suppressor of cytokine signaling 1，SOCS1），从而调节母体的免疫反应。此外，外泌体miRNA在PE的早期诊断中显示出潜力，有望成为预测PE的生物标志物。

关键词: 外泌体, 微RNAs, 外泌体小RNA, 先兆子痫, 细胞因子信号转导抑制因子1, 发病机制

Abstract:

Preeclampsia (PE) is a serious complication of pregnancy whose main symptoms include hypertension and multi-system organ damage, which seriously affects the health of mother and child. Termination of pregnancy is currently the preferred treatment choice for PE. Although the pathogenesis of PE has not been completely clarified, recent studies have shown that exosomes from different sources and the microRNAs (miRNAs) they carry play key roles in the development of PE, especially miRNAs, as the most representative type of exosomal small RNAs, can be involved in the pathophysiological process of PE through the regulation of trophoblast function and signaling pathways. In particular, exosomes miRNAs can inhibit suppressor of cytokine signaling 1 (SOCS1), thereby regulating the maternal immune responses. In addition, exosomal miRNAs show potential in the early diagnosis of PE and are expected to be biomarkers for the prediction of PE.

Key words: Exosomes, MicroRNAs, Exosomal small RNA, Pre-eclampsia, Suppressor of cytokine signaling 1 protein, Pathogenesis

张雯, 刘慧强. SOCS1与外泌体微小RNA在子痫前期发病机制中的作用[J]. 国际妇产科学杂志, 2025, 52(1): 94-98.

ZHANG Wen, LIU Hui-qiang. The Role of SOCS1 and Exosomal MicroRNA in the Pathogenesis of Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 94-98.

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