国际妇产科学杂志

国际妇产科学杂志 ›› 2018, Vol. 45 ›› Issue (4): 460-463.

• 综述 • 上一篇    下一篇

宫颈小细胞癌非手术治疗研究进展

杜靖然，王妍，杨永秀   

  1. 730000  兰州大学第一医院妇产科
  • 收稿日期:2018-04-23 修回日期:2018-06-15 出版日期:2018-08-15 发布日期:2018-08-15

Advances in Non-surgical Treatment of Small-cell Carcinoma of the Cervix

DU Jing-ran，WANG Yan，YANG Yong-Xiu   

  1. Department of Obstetrics and Gynecology，First Hospital of Lanzhou University，Lanzhou 730000，China
  • Received:2018-04-23 Revised:2018-06-15 Published:2018-08-15 Online:2018-08-15

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摘要： 宫颈小细胞癌（small-cell carcinoma of the cervix，SCCC）是罕见的神经内分泌恶性肿瘤，占宫颈癌的3%～5%，是一种具有高度侵袭性的宫颈癌，以早期淋巴结和血行播散为特征，即使在临床上病灶仅局限于骨盆，预后也很差。国际妇产科联盟（FIGO）Ⅰ～ⅡA期患者的5年总生存率为36.8%。广泛转移的SCCC患者，5年总生存率为0，而且复发性疾病是无法治愈的，并且复发疾病诊断后的生存期很短，通常只有7～8个月。SCCC经常快速地远处转移至肺、肝、脑、骨、胰腺和淋巴结，导致大多数情况下治疗失败。SCCC治疗以手术辅以放化疗为主，综述SCCC非手术治疗方法，旨在提高SCCC的非手术治疗效果，改善患者的预后。

关键词: 宫颈肿瘤, 癌, 小细胞, 抗肿瘤联合化疗方案, 放射疗法, 宫颈小细胞癌

Abstract: Small-cell carcinoma of the cervix (SCCC) is a rare neuroendocrine malignancy that accounts for 3%-5% of cervical cancer. It is a highly invasive cervical cancer characterized by early lymph node and hematogenous spread. Even if the lesion is clinically limited in the pelvis, the prognosis is also very poor. The 5-year overall survival rate for women in the FIGOⅠ-ⅡA period was 36.8%. The overall survival rate of SCCC patients with extensive metastasis was 0 in 5 years, and recurrent disease is incurable, and the survival time after diagnosis of recurrent disease is very short, usually only 7-8 months. SCCC often metastasizes rapidly to the lungs, liver, brain, bone, pancreas, and lymph nodes, leading to treatment failure in most cases. The treatment of SCCC is mainly based on surgery combined with radiotherapy and chemotherapy. Now we review its non-surgical treatment methods of SCCC and improve the prognosis of patients.

Key words: Uterine cervical neoplasms, Carcinoma, small cell, Antineoplastic combined chemotherapy protocols, Radiotherapy, Small-cell carcinoma of the cervix