关键词: 卵巢肿瘤, 小细胞癌, 高钙血症型, 诊断, 治疗, 预后

Abstract: Objective：To analyze the clinical characteristics, diagnosis, treatment and outcomes of patients with SCCOHT. Methods：A retrospective analysis was performed on clinical and pathological data of 7 patients with pathologically confirmed SCCOHT between 1994 and 2018. Results：The average age of 7 cases was  (23.4 ±9.9) years old, with 5 cases younger than 30 years old. There were 4 cases in stage I, 2 in stage III, and 1 in stage IV. Abdominal pain, bloating and pelvic mass were the most common clinical presentation. The affected ovary of 6 patients was on the right side, 1 patient was on the left. Five patients (71.4%) had elevated serum calcium and 6 (85.7%) had elevated serum CA125 level at the time of diagnosis. All 7 patients were treated with surgery and platinum-based combination chemotherapy. Only 1 patient received radiotherapy after surgery. During the follow-up period of 2-120 months, only 2 patients survived more than 3 years, and the remaining 5 patients all died within 2 years of onset. Conclusions：SCCOHT is an uncommon and highly malignant tumor that usually occurs in young females with a dismal prognosis. The clinical manifestations are nonspecific and immunohistochemistry is an efficient method for diagnosis. The traditional treatments for SCCOHT are surgery and adjuvant platinum-based chemotherapy. The optimal regimen needs further study.

Key words: Ovarian neoplasm, Small cell carcinoma, Hypercalcemic type, Diagnosis, Therapy, Prognosis