国际妇产科学杂志

国际妇产科学杂志 ›› 2018, Vol. 45 ›› Issue (6): 691-695.

• 论著 • 上一篇    下一篇

脂联素基因rs266729（-11377C/G）位点多态性与妊娠期糖尿病相关性的Meta分析

吴优，沈彦婷   

  1. 210009  南京，东南大学医学院形态中心（吴优），生物科学与医学工程学院（沈彦婷）
  • 收稿日期:2018-01-08 修回日期:2018-10-10 出版日期:2018-12-15 发布日期:2018-12-15

A Meta-Analysis on the Association between Adiponectin Gene rs266729(-11377C/G) and Gestational Diabetes Mellitus

WU You，SHEN Yan-ting   

  • Received:2018-01-08 Revised:2018-10-10 Published:2018-12-15 Online:2018-12-15

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摘要： 目的：系统评价脂联素基因rs266729（-11377C/G）位点多态性与妊娠期糖尿病（GDM）的相关性。方法：计算机检索PubMed、Web of Science、CBM、中国知网、万方和维普数据库，收集各数据库建库以来至2017年12月8日前国内外公开发表的有关脂联素基因rs266729（-11377C/G）位点多态性与GDM相关性的病例-对照研究。由2位研究者按照纳入与排除标准独立筛选文献、提取资料和评价质量后，采用RevMan 5.3软件进行Meta分析。结果：最终纳入7篇文献，其中中文文献2篇、英文文献5篇。共纳入943例GDM孕产妇和999例正常孕妇。Meta分析结果显示：rs266729（-11377C/G）位点基因型频率在2组孕妇中分布差异无统计学意义。GG vs. GC的合并OR（95%CI）值为0.87（0.59~1.28），GG vs. CC的合并OR（95%CI）值为1.03（0.71~1.48），GC vs. CC的合并OR（95%CI）值为1.12（0.91~1.39）。显性及隐性基因模型在2组孕妇之间分布差异也无统计学意义，GG+GC vs. CC的合并OR（95%CI）值为1.22（0.98~1.51），GG vs. GC+CC的合并OR（95%CI）值为0.95（0.66~1.36）。2组等位基因频率在其他种族亚组孕妇中分布差异有统计学意义（P＜0.05），其G vs. C的合并OR（95%CI）值为0.65 （0.52~0.83）；2组等位基因频率在中国汉族孕妇中分布差异无统计学意义（P＞0.05），其G vs. C的合并OR（95%CI）值为1.15 （0.91~1.45）。结论：其他种族孕妇的脂联素基因rs266729（-11377C/G）位点的多态性与GDM有关联，且该位点的次等位基因G是保护型基因，对GDM的预防和诊断具有一定价值。

关键词: 妊娠期糖尿病, 脂联素, rs266729（-11377C/G）, 多态性, Meta分析, 病例-对照研究

Abstract: Objective：To systematically review the association between rs266729(-11377C/G) of adiponectin gene and gestational diabetes mellitus (GDM). Methods: We electronically searched the following databases: PubMed, Web of Science, CBM, CNKI, WanFang Data, and VIP to identify all the case-control trials which was related to the association between rs266729(-11377C/G) of adiponectin gene and GDM. Two reviewers independently filtrated literature and extracted data according to the inclusion and exclusion criteria. Then, they assessed the quality of the included studies and performed meta-analysis using RevMan 5.3 software. Results: Totally 7 studies were recruited (943 GDM pregnant women and 999 normal pregnant women), including two Chinese studies and five English studies. The results of meta-analysis showed that there was no significant difference in the genotype frequency of rs266729(-11377C/G) between the two groups. The pooled OR values and 95%CI values of GG vs. GC, GG vs. CC and GC vs. CC were 0.87 (0.59-1.28), 1.03 (0.71-1.48), 1.12 (0.91-1.39), respectively. There was also no significant difference in the dominant and recessive genetic models between the two groups. The pooled OR value of dominant genetic model was 1.22 (0.98-1.51), and the pooled OR value of recessive genetic model was 0.95 (0.66-1.36). For the allele frequencies, a significant difference was found between the two groups in non-han Chinese (P＜0.05), the pooled OR(95%CI) value of G vs. C was 0.65 (0.52-0.83), while there was no significant difference between the two groups in the Han Chinese women (P＞0.05), the pooled OR(95%CI) value of G vs. C was 1.15 (0.91-1.45). Conclusions: rs266729 (-11377C/G) of adiponectin gene in non-han Chinese pregnant women was associated with GDM. The sub-allele gene G of this site was a protective gene, which would be of some value in the prevention and diagnosis of GDM.

Key words: Gestational diabetes mellitus, Adiponectin;, rs266729(-11377C/G), Polymorphism, Meta-analysis, Case-control studies