国际妇产科学杂志

国际妇产科学杂志 ›› 2019, Vol. 46 ›› Issue (2): 134-137.

• 综述 • 上一篇    下一篇

环状RNA的分子生物学功能及其在卵巢癌中的研究

蔡雨晗，景兰凯，林茜茜，李华   

  1. 100191 北京大学第三医院妇产科
  • 收稿日期:2018-12-07 修回日期:2019-01-14 出版日期:2019-04-15 发布日期:2019-04-15

Molecular Biological Functions of Circular RNA and Its Role in Ovarian Cancer

CAI Yu-han，JING Lan-kai，LIN Qian-qian，LI Hua   

  1. Department of Obstetrics and Gynecology，Peking University Third Hospital，Beijing 100191，China
  • Received:2018-12-07 Revised:2019-01-14 Published:2019-04-15 Online:2019-04-15

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摘要： 环状RNA（circular RNA，circRNA）是一种在人体内广泛存在的不具有5′端帽子和3′端尾巴的共价闭合环状非编码RNA，较线性RNA更具稳定性，组织特异性强，在正常组织及肿瘤组织中的表达有显著差异，其特殊的分子生物学功能尤其是微小RNA（microRNA，miRNA）分子海绵作用，使其有望成为新的肿瘤标志物和分子靶向治疗靶标。近年研究发现circRNA可以通过多种机制调控恶性肿瘤的增殖与转移，在恶性肿瘤的早期诊断、治疗、预后以及肿瘤对放化疗敏感性等方面有指导作用。但是，目前circRNA在卵巢癌中的功能和调控机制研究尚处于初始阶段，仅有少量的报道和研究。综述circRNA的分子生物学功能及其在卵巢癌中的功能和调控机制。

关键词: RNA, 微RNAs, 卵巢肿瘤, 环状RNA

Abstract: Circular RNA (circRNA), a novel class of long noncoding RNAs, is characterized by a covalently closed continuous loop without 5′ or 3′ polarities structure and have been widely found in human bodies. CircRNA is more stable than liner RNA. It has better tissue specificity and the expression levels in normal tissue and tumor tissue are different. Its molecular biological functions especially the microRNA(miRNA) sponge make it possible to act as the new tumor biomarker and the new target for targeted therapy. Recent studies have revealed that circRNA plays an important role in tumorgenesis, early diagnosis, therapy, prognosis, radiosensitivity and chemosensitivity in malignant tumors. However, the research on the function and regulation machanism of circRNA in ovarian cancer is still in the initial stage and rare at present. This article reviews the researches on the molecular biological characteristics and functions of circRNAs in ovarian cancer.

Key words: RNA, MicroRNAs, Ovarian neoplasms, Circular RNA