国际妇产科学杂志

国际妇产科学杂志 ›› 2019, Vol. 46 ›› Issue (2): 146-149.

• 论著 • 上一篇    下一篇

宫颈透明细胞癌13例临床分析

胡瑞，侯文静，张梦真   

  1. 450052 郑州大学第一附属医院妇产科
  • 收稿日期:2018-11-27 修回日期:2019-01-26 出版日期:2019-04-15 发布日期:2019-04-15
  • 通讯作者: 张梦真，E-mail：13683806877@163.com E-mail:13683806877@163.com

Clear Cell Adenocarcinoma of Cervical：Clinical Analysis of 13 Cases

HU Rui，HOU Wen-jing，ZHANG Meng-zhen   

  1. Department of Obstetrics and Gynecology，The First Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，China
  • Received:2018-11-27 Revised:2019-01-26 Published:2019-04-15 Online:2019-04-15
  • Contact: ZHANG Meng-zhen，E-mail：13683806877@163.com E-mail:13683806877@163.com

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摘要： 目的：探讨宫颈透明细胞癌的临床特点、治疗及预后。方法：回顾性分析2013年4月—2017年12月郑州大学第一附属医院收治的13例原发宫颈透明细胞癌患者的临床资料及随诊资料，分析其临床特征、病理特点、治疗方案及预后情况。结果：13例患者平均年龄（53.6±13.9）岁，9例（69.2%）大于40岁，4例（30.8%）小于40岁，其中2例青少年患者。临床分期：Ⅰ期6例（46.15%），Ⅱ期6例（46.15%），Ⅲ期1例（7.7%）；12例接受手术+放化疗，其中3例行新辅助化疗，9例术后放疗和（或）化疗，1例单纯放疗；中位随访时间24个月（6～60个月），4例死亡，2例多发转移，第1、2、5年累积生存率分别为12/13、11/13和9/13。结论：宫颈透明细胞癌发病率低，临床表现无特异性，伴淋巴结转移者预后极差，手术加放化疗的个体化综合治疗方案能明显改善患者病情及预后。

关键词: 宫颈肿瘤, 腺癌, 透明细胞, 治疗, 预后

Abstract: Objective：To discuss the clinical and pathological characteristics, therapy and prognosis of clear cell adenocarcinoma of cervical(CCAC). Methods: We performed a retrospective review of 13 patients with CCAC who were diagnosed and treated at the First Affiliated Hospital of Zhengzhou University from April 2013 to December 2017. Result: The age of the patients was (53.6±13.9) years，of which 9 (69.2%) were older than 40 years and 4 (30.8%) were younger than 40 years, 2 were adolescents. The International Federation of Gynecology and Obstetrics stage: 46.15% (n=6) stage I, 46.15% (n=6) stage II, 7.7% (n=1) stage III. Twelve patients underwent surgery followed by radiotherapy and chemotherapy, including 3 patients treated by neoadjuvant chemotherapy, 9 postoperative adjuvant radiotherapy and/or chemotherapy. One patient was treated by radiotherapy alone. The median follow-up time was 24 months (6-60 months). 4 patients died and 2 patients had multiple metastases. The 1-year, 2-year and 5-year survival rates were 12/13、11/13 and 9/13, respectively. Conclusions: CCAC has low incidence, nonspecific clinical manifestations and poor prognosis with lymph node metastasis. The individualized comprehensive treatment of surgery followed by radiotherapy and chemotherapy can significantly improve the patient′s condition.

Key words: Uterine cervical neoplasms, Adenocarcinoma, clear cell, Therapy, Prognosis