关键词: RNA, 长链非编码, 宫颈肿瘤, 信号传导, 生物标记, 治疗

Abstract: Cervical cancer is the second largest female malignant tumor after breast cancer. The main pathogenic factor of cervical cancer is human papillomavirus (HPV) infection. The incidence and mortality of cervical cancer have been decreased thanks to the use of HPV vaccine and advances in surgery and chemoradiotherapy. However, metastasis, recurrence and drug resistance are still great challenges in clinical therapeutics. Long-stranded non-coding RNA (lncRNA) is longer than 200 nt, most of which can not encode proteins, and only a few of which are translated into peptides. LncRNAs such as H19 and HOTAIR have been proved to play an important role in the initiation and progression of cervical cancer, and are closely related to the abnormal activation of PI3K/Akt, Wnt and other signaling pathways. LncRNA involved in the development of cervical cancer and its signal pathways are reviewed to explore potential biomarkers for diagnosis or prediction of prognosis, or effective targets for gene therapy.

Key words: RNA, long noncoding, Uterine cervical neoplasms, Signal transduction, Biomarkers, Therapy