国际妇产科学杂志

国际妇产科学杂志 ›› 2016, Vol. 43 ›› Issue (1): 84-86.

• 论著 • 上一篇    下一篇

sTWEAK、TNF-α和IL-10在卵巢上皮性癌患者血清中的表达及其意义

黄毓丽，邱丽华   

  1. 202150 上海交通大学医学院附属新华医院崇明分院妇产科（黄毓丽）；上海交通大学医学院附属仁济医院妇产科，上海市妇科肿瘤重点实验室（邱丽华）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-02-15 发布日期:2016-02-15
  • 通讯作者: 邱丽华

Serum sTWEAK，TNF-α and IL-10 Expression and Their Clinical Significance in Epithelial Ovarian Cancer Patients

HUANG Yu-li，QIU Li-hua   

  1. Department of Obstetrics and Gynecology，Xinhua Hospital Chongming Branch，School of Medicine，Shanghai Jiao Tong University，Shanghai 202150，China（HUANG Yu-li）；Department of Obstetrics and Gynecology，Shanghai Key Laboratory of Gynecologic Oncology，Renji Hospital，School of Medicine，Shanghai Jiao Tong University，Shanghai 200127，China（QIU Li-hua）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-02-15 Online:2016-02-15
  • Contact: QIU Li-hua

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摘要： 目的：检测上皮性卵巢癌（epithelial ovarian cancer，EOC）患者外周血可溶性肿瘤坏死因子样凋亡微弱诱导剂（soluble tumor necrosis factor-like weak inducer of apoptosis，sTWEAK）、肿瘤坏死因子α（TNF-α）和白细胞介素10（IL-10）的表达水平，并分析其临床意义。方法：选取2010年1月—2014年2月在上海交通大学附属仁济医院住院手术的EOC患者和良性上皮性卵巢肿瘤患者共43例，采用酶联免疫吸附试验（ELISA）方法检测外周血血清中sTWEAK、TNF-α和IL-10的表达水平。结果：①与良性上皮性卵巢肿瘤组相比，EOC组的sTWEAK的表达水平升高（P＜0.05），TNF-α的表达水平升高（P＜0.01），IL-10的表达水平差异无统计学意义（P＞0.05）。②sTWEAK、TNF-α和IL-10在EOC患者血清中的表达水平在不同的临床分期、病理类型、组织学分级以及腹水有无肿瘤细胞者中差异均无统计学意义（P＞0.05）。③2组患者中sTWEAK的表达与TNF-α呈正相关（rs=0.505，P=0.001），而sTWEAK与IL-10无相关性（rs=0.154，P=0.325）。结论：sTWEAK、TNF-α与EOC的发生密切相关，sTWEAK高表达者血清TNF-α表达也高。

关键词: 卵巢肿瘤, 肿瘤坏死因子α, 白细胞介素10, 可溶性肿瘤坏死因子样凋亡微弱诱导剂, 酶联免疫吸附测定

Abstract: Objective：To explore the expression level and clinical implications of serum sTWEAK，TNF-α and IL-10 in epithelial ovarian cancer（EOC） patients. Methods：Totally 43 patients with EOC（EOC group） and benign epithelial ovarian tumor （BOT group） were selected from Renji Hospital，School of Medicine，Shanghai Jiao Tong University. These patients were admitted to the hospital during the period from January 2010 to February 2014. The levels of serum sTWEAK，TNF-α and IL-10 were detected by ELISA. Results：①Compared to the BOT group，the expression levels of sTWEAK （P＜0.05） and TNF-α（P＜0.01） were significantly increased in the EOC group，the elevation of IL-10 level was not significant （P＞0.05）. ②The expression levels of sTWEAK，TNF-α and IL-10 in peripheral serum in EOC group were not significantly different with different clinical stages，pathological types， histological grade and ascites presence of tumor cells（P＞0.05）. ③In both two groups，the expression level of sTWEAK was positively correlated with serum TNF-α（rs=0.505，P=0.001）and was no correlation with serum IL-10（rs=0.154，P=0.325）. Conclusions：Serum sTWEAK and TNF-α expression levels were closely correlated with the pathogenesis of EOC. In patients with high sTWEAK expression，the expression of TNF-α was dominant.

Key words: Ovarian neoplasms, Tumor necrosis factor-alpha, Interleukin-10, sTWEAK, Enzyme-linked immunosorbent assay