LncRNA HOTAIR在妇科恶性肿瘤中的研究进展

doi:10.12280/gjfckx.20250334

摘要/Abstract

摘要：

随着高通量测序技术的快速发展，长链非编码RNA（long non-coding RNA，lncRNA）HOX转录反义RNA（HOX transcript antisense RNA，HOTAIR）在妇科恶性肿瘤中的作用逐渐被揭示。研究表明，HOTAIR在宫颈癌、卵巢癌和子宫内膜癌中普遍高表达，且与肿瘤的进展、转移及耐药性密切相关。HOTAIR通过调控Wnt/β-联蛋白、转化生长因子-β（transforming growth factor-β，TGF-β）/上皮-间质转化（epithelial-mesenchymal transition，EMT）、Notch及磷脂酰肌醇3激酶（phosphoinositide 3-kinase，PI3K）/蛋白激酶B（protein kinase B，Akt）等信号通路，参与肿瘤的增殖、侵袭、转移和耐药等过程。此外，其基因多态性（如单核苷酸多态性）与妇科恶性肿瘤的易感性密切相关，作为竞争性内源RNA（competing endogenous RNA，ceRNA）调控微小RNA功能的特性进一步凸显了其在肿瘤分子调控中的关键作用。HOTAIR不仅可作为潜在的分子标志物用于妇科恶性肿瘤的诊断与预后评估，还可能成为未来个体化治疗策略的重要靶点。

关键词: RNA, 长链非编码, 卵巢肿瘤, 宫颈肿瘤, 子宫内膜肿瘤, 抗药性, 肿瘤, 信号传导, 细胞增殖, HOTAIR

Abstract:

With the rapid development of high-throughput sequencing technology, the role of long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) in gynecological malignant tumors has been gradually revealed. Studies have shown that HOTAIR is generally highly expressed in cervical cancer, ovarian cancer, and endometrial cancer, and is closely related to tumor progression, metastasis, and drug resistance. HOTAIR participates in the processes of tumor proliferation, invasion, metastasis, and drug resistance by regulating signaling pathways such as Wnt/β-catenin, transforming growth factor-β (TGF-β)/epithelial-mesenchymal transition (EMT), Notch, and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt). In addition, its genetic polymorphisms (such as single nucleotide polymorphisms) are closely related to the susceptibility of gynecological malignant tumors. Its characteristic of regulating microRNA function as a competing endogenous RNA (ceRNA) further highlights its key role in tumor molecular regulation. HOTAIR can not only serve as a potential molecular marker for the diagnosis and prognostic evaluation of gynecological malignant tumors, but may also become an important target for future individualized treatment strategies.

Key words: RNA, long noncoding, Ovarian neoplasms, Uterine cervical neoplasms, Endometrial neoplasms, Drug resistance, neoplasm, Signal transduction, Cell proliferation, HOTAIR

周玲玲, 宋建东, 萨日娜. LncRNA HOTAIR在妇科恶性肿瘤中的研究进展[J]. 国际妇产科学杂志, 2025, 52(5): 481-485.

ZHOU Ling-ling, SONG Jian-dong, Sarina . Research Progress of LncRNA HOTAIR in Gynecological Malignant Tumors[J]. Journal of International Obstetrics and Gynecology, 2025, 52(5): 481-485.

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