关键词: 心脏缺损, 先天性, 妊娠, Meta分析, 心脏矫正术

Abstract: Objective：To evaluate the effect of cardiac correction on pregnancy outcomes in women with congenital heart disease. Methods：The studies published before September 2018 about the effect of cardiac correction on pregnancy outcomes in women with congenital heart disease were searched in PubMed, Cochrane Library, CNKI, VIP, WanFang data. Quality assessment and data collection were performed. The Meta-analysis was performed using RevMan 5.3 software. Results：A total of 17 cohort studies were included, including 1 181 patients. There were 457 patients in the operation group and 724 patients in the non-operation group. The results of the Meta-analysis showed that，for women with congenital heart disease, pre-pregnancy cardiac correction can improve cardiac function and reduce the incidence of heart failure，cesarean section, premature birth, fetal growth restriction, small for gestational age infant, neonatal asphyxia and perinatal mortality, all of which are statistically significant (P＜0.05). However, the difference between the operation group and the non-operation group was not statistically significant in terms of maternal mortality and neonatal heart disease incidence (P＞0.05). Conclusions：Women with congenital heart disease who underwent cardiac surgery correction before pregnancy generally had better pregnancy outcomes than women who did not undergo cardiac surgery correction.

Key words: Heart defects, congenital, Pregnancy, Meta-analysis, Cardiac surgical correction