国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (6): 394-396.

• 综述 • 上一篇    下一篇

妊娠期糖尿病治疗进展

米念荣， 孟 超 ，王淑芳   

  1. 250012 济南，山东大学医学院（米念荣，孟超）；山东大学附属济南市中心医院（王淑芳）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-12-15 发布日期:2010-12-15

The Development of Therapy of GDM

MI Nian-rong，MENG Chao，WANG Shu-fang   

  1. School of Medicine, Shan dong University, Jinan 250012, China（MI Nian-rong, MENG Chao）；Jinan Central Hospital Affiliated to Shandong University，Jinan 250013，China（WANG Shu-fang）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-12-15 Online:2010-12-15

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摘要： 妊娠期糖尿病（GDM）是妊娠妇女常见围生期并发症之一，对母婴危害较大，属高危妊娠。其发病与胰岛素抵抗（IR）和胰岛β细胞分泌功能障碍有关。治疗关键在于严格控制血糖，减少因高血糖对母婴的不良影响，并防止代谢并发症及产科并发症。胰岛素是GDM药物治疗的首选，研究表明，超短效胰岛素类似物对GDM同样安全、有效。口服降糖药（OHA）在GDM中的应用已成为最新研究热点。

关键词: 糖尿病, 妊娠, 胰岛素抗药性, 运动疗法, 降血糖药, 投药, 口服, 二甲双胍

Abstract: Gestational diabetes mellitus（GDM） is a common perinatal complication， belongs to high-risk pregnancy，which is harmful to mother and fetus. The pathogenesis of GDM is associated with insulin resistance（IR） and dysfunction of beta cells. Good glycemic control should be highly addressed to reduce the metabolic abnormalities and perinatal complication. A rapid-acting human insulin analogue is also safe and effective compared with regular human insulin. Oral antidiabetic drug has became the lastest research hotspot. This review will examine the development of therapy of GDM.

Key words: Diabetes, gestational, Insulin resistance, Exercise therapy, Hypoglycemic agents, Administration, Metformin