关键词: RNA, 长链非编码；, 自噬；, 宫颈肿瘤；, 诊断；, 癌

Abstract: Cervical cancer is the fourth leading cause of cancer related death worldwide, with high incidence rate and mortality. In recent years, long non-coding RNAs (lncRNAs) have been proved to be related to tumor progression, invasion, treatment resistance and other pathogenic processes, and become a new biomarker for diagnosis and prognosis of cervical cancer. Autophagy helps to maintain sufficient cancer microenvironment to provide nutritional support under adverse conditions such as hunger and hypoxia. In recent years, autophagy induction has been proved to be an important mechanism in the development of cervical cancer. However, the specific molecular mechanism of lncRNAs in autophagy and cervical cancer has not been fully studied. This paper reviews the relationship between lncRNAs, autophagy and cervical cancer, and focuses on several kinds of lncRNAs that promote the development of cervical cancer by regulating autophagy, which provides a new way to study the pathogenesis of cervical cancer, and provides an important reference value for the screening of valuable biomarkers for diagnosis of cervical cancer.

Key words: RNA, long noncoding；, Autophagy；, Uterine cervical neoplasms；, Diagnosis；, Carcinoma