国际妇产科学杂志

国际妇产科学杂志 ›› 2020, Vol. 47 ›› Issue (6): 712-715.

• 综述 • 上一篇    下一篇

雌激素及炎症因子与绝经后骨质疏松症相关研究进展

陈怡洁，金雪静，王雪，杜旖旎，盛祝梅，张治芬   

  1. 310053  杭州，浙江中医药大学（陈怡洁，张治芬）；杭州市妇产科医院（金雪静，盛祝梅）；南京医科大学（王雪，杜旖旎，张治芬） 
  • 收稿日期:2020-04-15 修回日期:2020-08-09 出版日期:2020-12-15 发布日期:2020-12-11
  • 通讯作者: 张治芬，E-mail：zhangzf@zju.edu.cn E-mail:zhangzf@zju.edu.cn
  • 基金资助:
    浙江省医药卫生重大科技计划项目（WKJ-ZJ-2010）

Research Progress on the Relationship between Estrogen, Inflammatory Factors and Postmenopausal Osteoporosis

CHEN Yi-jie, JIN Xue-jing, WANG Xue, DU Yi-ni, SHENG Zhu-mei, ZHANG Zhi-fen   

  1. Zhejiang Chinese Medical University, Hangzhou 310053, Chiｎａ （ＣHEN Yi-jie, ZHANG Zhi-fen）;  Hangzhou Women′s Hospital, Hangzhou 310001, Chinａ （JIN Xue-jing, SHENG Zhu-mei）; Nanjing Medical University, Nanjing 211166, Chinａ （WANG Xue, DU Yi-ni, ZHANG Zhi-fen）
  • Received:2020-04-15 Revised:2020-08-09 Published:2020-12-15 Online:2020-12-11
  • Contact: ZHANG Zhi-fen, E-mail: zhangzf@zju.edu.cn E-mail:zhangzf@zju.edu.cn

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摘要： 绝经后女性体内雌激素水平骤然下降，导致破骨细胞功能增强，而成骨细胞功能减退，导致骨重建失衡。同时由于年龄的增长，绝经后女性的生理机能和免疫功能下降，并且机体长期处于慢性炎症状态。许多炎症性疾病如类风湿关节炎、炎症性肠病等都伴随明显骨丢失。炎症因子可与免疫系统、骨骼重塑之间相互作用，其与骨质疏松的发生进展密切相关。雌激素可通过多种方式调控骨重建的进程和炎症的发生发展。既往通常单独研究雌激素或炎症与骨质疏松症的关系, 越来越多的证据证明这两种机制是相互关联的，深入研究雌激素可能通过调节炎症过程从而影响破骨细胞的活动，了解雌激素如何调节炎性因子可为治疗骨质疏松症提供新的理论依据。本文将对雌激素及炎症因子与绝经后骨质疏松症的相关性研究进行综述。

关键词: 骨质疏松, 绝经后；, 雌激素类；, 炎症因子；, 炎症介导素类；, 骨密度

Abstract: Due to the sudden drop in estrogen levels, postmenopausal women are in bone reconstruction imbalance. Osteoclast function enhanced, and osteoblast function decreased. At the same time, due to the increase of age, the physiological and immune functions of postmenopausal women decrease, and the body is in chronic inflammation state for a long time. Various inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease are associated with significant local or systemic bone loss. Inflammatory factors interact with the immune system and bone remodeling, and are closely related to the progress of osteoporosis. Estrogen regulate the process of bone reconstruction, the occurrence and development of inflammation in various ways. In the past, the relationship between estrogen and osteoporosis, or inflammation and osteoporosis was usually studied separately. In recent years, there is evidence that estrogen and inflammation are interrelated in postmenopausal osteoporosis. The decline of estrogen may cause postmenopausal osteoporosis by influencing the level of inflammation and exploring how estrogen regulates inflammatory factors may provide a new theoretical basis for the treatment of osteoporosis. This article reviews estrogen and inflammatory factors in postmenopausal osteoporosis as following.

Key words: Osteoporosis, postmenopausal, Estrogens, Inflammatory factors, Inflammation mediators, Bone density