循环肿瘤DNA在卵巢癌诊治中的研究进展

doi:10.12280/gjfckx.20210694

摘要/Abstract

摘要：

卵巢癌（ovarian cancer,OC）近年发病率逐渐增高,具有高复发率、高病死率的特点,成为危害女性生命健康的主要疾病之一。目前在卵巢癌的早期检测和筛查、复发监测、治疗评估方面尚缺乏有效的检测手段。循环肿瘤DNA（circulating tumor DNA,ctDNA）是肿瘤细胞释放进入血液循环中的DNA片段,具有无创、实时、可反映肿瘤基因特征的优点。随着ctDNA检测技术的提升和对ctDNA研究的深入,ctDNA在OC早期诊断、肿瘤分子分型及治疗监测中表现出较传统组织学、血清学和影像学检测方法更明显的优势。综述ctDNA的提取和检测方法,及其在OC诊治中的最新研究进展,为OC诊治提供新思路。

关键词: DNA,肿瘤, 卵巢肿瘤, 诊断, 治疗, 预后

Abstract:

Ovarian cancer (OC) has become one of the major diseases threatening women′s life and health due to its high recurrence rate and mortality with its incidence rate increasing. At present, there is a lack of effective methods for early detection, screening, recurrence monitoring and treatment evaluation of OC. Circulating tumor DNA (ctDNA) is fragment of DNA released by tumor cells into the blood circulation. It has the advantages of noninvasive, real-time, and can reflect the characteristics of tumor genes. Recent years, with the advancement of ctDNA detection technology and the in-depth research of ctDNA, ctDNA has shown more advantages than traditional histological, serological and imaging detection methods in the early diagnosis, tumor molecular typing and treatment monitoring of OC. This paper will review the extraction and detection methods of ctDNA and its latest research progress in the diagnosis and treatment of OC, to provide new ideas for the diagnosis and treatment of OC.

Key words: DNA,neoplasm, Ovarian neoplasm, Diagnosis, Therapy, Prognosis

于长清, 汪希鹏. 循环肿瘤DNA在卵巢癌诊治中的研究进展[J]. 国际妇产科学杂志, 2022, 49(1): 19-23.

YU Chang-qing, WANG Xi-peng. Research Progress of Circulating Tumor DNA in Diagnosis and Treatment of Ovarian Cancer[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 19-23.

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