国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (6): 514-516.

• 论著 • 上一篇    下一篇

胎盘组织COMT的表达及其与子痫前期发病的关系

赖宝玲, 王晨虹, 王 洁 , 吴惠芬, 周 璐   

  1. 518028 广东省深圳市，南方医科大学附属深圳妇幼保健院产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-12-15 发布日期:2013-12-15
  • 通讯作者: 王晨虹

Expression of Catechol-O-Methyltransferase in Placenta and Its Relationship with Preeclampsia

LAI Bao-ling，WANG Chen-hong，WANG Jie，WU Hui-fen，ZHOU Lu   

  1. Department of Obstetrics，Shenzhen Maternity and Child Healthcare Hospital，South Medical University，Shenzhen 518028，Guangdong Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-12-15 Online:2013-12-15
  • Contact: WANG Chen-hong

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摘要： 目的：检测子痫前期患者胎盘组织儿茶酚氧位甲基转移酶（COMT）的表达，探讨其与子痫前期发病的关系。方法：收集15例子痫前期患者（子痫前期组）及15例健康妊娠妇女（对照组）的临床资料及产后胎盘组织，采用实时荧光定量聚合酶链反应（PCR）技术检测2组妊娠妇女胎盘组织COMT mRNA的水平。结果：子痫前期组胎盘组织COMT mRNA水平明显低于对照组（P＜0.001），且胎盘组织COMT mRNA水平与血清尿酸、24 h尿蛋白定量、平均动脉压呈负相关（均P＜0.001）。结论：COMT在子痫前期妊娠妇女胎盘组织中呈低表达，可能与子痫前期的发病有关。

关键词: 先兆子痫, 儿茶酚O-甲基转移酶, 聚合酶链反应, 胎盘

Abstract: Objective：To investigate the expression of catechol-O-methyl- transferase（COMT） in placenta from patients with preeclampsia and the relationship between COMT and the pathogenesis of preeclampsia. Methods：15 patients with preeclampsia and 15 normal pregnant women were enrolled. Clinical characteristics and placental tissue were collected. placental COMT expression was determined by quantitative real-time PCR technique. Results：The level of COMT mRNA in Placenta from the preeclampsia group was significantly decreased than that in the normal pregnant women（P＜0.001）．Adjusted by age and body mass index（BMI），the COMT expression was negatively correlated with serum uric acid，24-hour urine protein and mean artery pressure（all P＜0.001）. Conclusions：The decreased expression of COMT in placenta from preeclamptic patients suggests that COMT may be involved in the pathogenesis of preeclampsia.

Key words: Pre-eclampsia, Catechol O-methyltransferase, Polymerase chain reaction, Placenta