国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (6): 510-513.

• 论著 • 上一篇    下一篇

子痫前期患者血清内脂素水平与血脂代谢及胰岛素抵抗的相关性

吴晶晶, 颜建英   

  1. 362000 福建省泉州市，福建医科大学附属第二医院妇产科（吴晶晶）；福建省妇幼保健院妇产科（颜建英）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-12-15 发布日期:2013-12-15
  • 通讯作者: 颜建英

The Levels of Visfatin，Lipid Metabolism and Insulin Resistance and Their Relationship in Women with Preeclampsia

WU Jing-jing，YAN Jian-ying   

  1. Department of Obstetrics and Gynecology，the Second Affiliated Hospital，Fujian Medical University，Quanzhou 362000，Fujian Province, China（WU Jing-jing）；Department of Obstetrics and Gynecology，Fujian Maternity and Children Health Hospital，Fuzhou 350001，China（YAN Jian-ying）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-12-15 Online:2013-12-15
  • Contact: YAN Jian-ying

PDF (PC)

4775

被引次数

8

摘要： 目的：探讨血清内脂素、血脂代谢及胰岛素抵抗与子痫前期发病的关系。方法：选择2010年7月—2011年1月在福建医科大学附属第二医院产检和住院分娩的96例子痫前期妊娠妇女，按病情轻重分为轻度子痫前期组（35例）和重度子痫前期组（61例）；另选同期正常妊娠晚期妇女96例作为对照组。采用酶联免疫吸附法检测妊娠妇女血清内脂素与胰岛素水平；采用稳态模型评估法计算胰岛素抵抗指数（HOMA-IR）；记录临床相关指标，包括妊娠妇女入院时体质量指数、收缩压（SBP）、舒张压（DBP）、血脂和血糖水平等进行相关性分析。结果：①子痫前期组妊娠妇女血清内脂素水平高于对照组，且重度子痫前期组高于轻度子痫前期组（均P＜0.05）。②子痫前期组血清三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL）、载脂蛋白B（ApoB）、空腹血清胰岛素（FINS）及HOMA-IR水平均高于对照组，而高密度脂蛋白胆固醇（HDL）、载脂蛋白A1（ApoA1）低于对照组（均P＜0.05）。③子痫前期组血清内脂素水平与TG、SBP、DBP及HOMA-IR均呈正相关（P＜0.01）。结论：子痫前期患者血清内脂素表达升高可能与子痫前期的发生、进展相关；血脂代谢异常及胰岛素抵抗与子痫前期患者内脂素表达升高有关，可能参与高内脂素促发子痫前期的发病机制。

关键词: 先兆子痫, 烟酰胺磷酸核糖基转移酶, 胰岛素抗药性, 脂类, 血压

Abstract: Objective：The purpose of this study was to detect the serum levels of visfatin，lipid metabolism and insulin resistance in preeclampsia（PE），and to discuss their roles in the pathogenesis of PE. Methods：A total of 96 women with PE and 96 normal pregnant women as control participated in this study. All cases are admitted to the Second Affiliated Hospital for delivery from July 2010 to January 2011. Patients with PE were divided into severe PE group（n=61） and mild PE group（n=35）. Enzyme-linked immunosorbent assay（ELISA） was used to detect the levels of visfatin. Radioimmunoassay assay was used to detect the levels of fasting insulin. Homeostasis model assessment insulin resistance index（HOMA-IR）. Furthermore，clinical and biochemical parameters were recorded，such as body mass index（BMI），systolic blood pressure（SBP），diastolic blood pressure（DBP），and to conduct the correlation analysis. Results：①The level of serum visfatin in PE group significantly elevated than that in control group，the level in severe PE group significantly elevated than that in mild PE group（P＜0.05）. ② In PE groups，the serum visfatin were positively related to the serum TG，TC，LDL，ApoB，FINS and HOMA-IR，while the serum visfatin was negatively related to the serum HDL（P＜0.05）. ③In PE groups，the serum levels of visfatin were positively related to the serum TG，SBP，DBP，and HOMA-IR（P＜0.01）. Conclusions：Elevated visfatin expression in serum may be associated with the pathogenesis and development of preeclampsia. Dyslipidemia and insulin resistance may be associated with elevated visfatin expression in patients with PE，and may be related to participation in the pathogenesis of preeclampsia.

Key words: Pre-eclampsia, Nicotinamide phosphoribosyltransferase, Insulin resistance, Lipids, Blood pressure