关键词: 生物节律, 先兆子痫, 昼夜节律, 时间治疗学, 钟基因

Abstract:

Preeclampsia (PE) is a common complication of pregnancy and serious international public health problem, which endangering maternal and infant health. Although risk factors for PE have been demonstrated to include obesity, diabetes, and pre-pregnancy hypertension, its pathogenesis has not been fully elucidated. The vast majority of physiological processes in mammals are regulated by biological rhythm, and the disruption of biological rhythm has been shown to be associated with numerous diseases, such as cardiovascular disease, diabetes and breast cancer. Although PE is characterized by a series of biological rhythm, such as 24-hour variability in blood pressure in PE patients, "reversed nocturnal" blood pressure is associated with more severe target organ damage of PE, and superior prophylactic protection with nocturnal aspirin administration. The question of whether variation in biological rhythm is a risk factor for PE, or PE is associated with abnormal biological rhythm has not yet been clarified. The correlation between biorhythms and PE through literature study, including the expression of clock genes in the placenta and its relationship with PE, the biological rhythm of blood pressure, chronotherapy in the prevention of PE and disruption of biological rhythm and the risk of PE, in order to enlighten the necessity of further study on the potential association between biorhythms/circadian clock gene and PE in the future.

Key words: Biorhythm, Pre-eclampsia, Circadian rhythm, Chronotherapeutics, Biological clock genes