不同来源外泌体在子痫前期发病和治疗中的作用

doi:10.12280/gjfckx.20230727

摘要/Abstract

摘要：

子痫前期（preeclampsia，PE）是妊娠期严重的并发症之一，严重威胁孕产妇及胎儿的生命，然而目前PE具体的发病机制和有效的治疗方法尚不清楚。外泌体是由细胞分泌并含有多种成分的膜性囊泡，具有不同的生物学功能，如细胞间通讯、生物标志物等功能可以为PE提供新型的早期筛查和治疗模型，且不同来源的外泌体（尤其是胎盘来源外泌体和间充质干细胞来源外泌体）可在PE中发挥不同的作用，如胎盘来源外泌体参与PE中免疫调节过程，间充质干细胞来源外泌体具有促进血管内皮细胞增殖与迁移等功能。此外，还有多种来源的外泌体与PE的关系仍需研究。综述不同来源外泌体在PE发病机制和治疗方面的研究进展。

关键词: 外泌体, 先兆子痫, 胎盘, 生物标记, 治疗

Abstract:

Preeclampsia (PE) is one of the most serious complications of pregnancy, which threatens the lives of pregnant women and fetuses. However, the pathogenesis and effective treatments of PE are still unclear. Exosomes are membrane vesicles secreted by cells and contain a variety of components. They have different biological functions, such as cell-to-cell communication and serving as biomarkers, which may provide new models for early screening and treatment of PE. And exosomes of different origins (especially placenta- and mesenchymal stem cell-derived exosomes) can play different roles in PE. For example, placenta-derived exosomes are involved in immune regulation processes in PE, while mesenchymal stem cell-derived exosomes promote endothelial cell proliferation and migration. In addition, the relationship between PE and exosomes from other sources still needs to be clarified. This article reviews the research of exosomes from different sources in the pathogenesis and treatment of PE.

Key words: Exosomes, Pre-eclampsia, Placenta, Biomarkers, Therapy

孟斐, 刘慧强. 不同来源外泌体在子痫前期发病和治疗中的作用[J]. 国际妇产科学杂志, 2024, 51(1): 10-14.

MENG Fei, LIU Hui-qiang. The Role of Exosomes from Different Sources in Pathogenesis and Treatment of Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2024, 51(1): 10-14.

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