关键词: 妊娠末期, 因子Ⅺ缺乏, 活化部分凝血活酶时间, 血浆治疗, 多学科诊疗

Abstract:

Congenital factor Ⅺ deficiency is a rare autosomal recessive inherited disease. Physiological changes during pregnancy may aggravate coagulation abnormalities, increasing the risk of intrapartum and postpartum hemorrhage and posing a serious threat to maternal and fetal safety. We report a case of a 32-year-old patient at 39⁺¹ weeks of gestation who was found to have prolonged activated partial thromboplastin time (APTT) during pregnancy. Congenital factor Ⅺ deficiency was confirmed by coagulation factor assays. Through multi-disciplinary team consultation, fresh frozen plasma transfusion was administered to correct the coagulation function. Successful vaginal trial of labor was achieved under close monitoring, with favorable maternal and neonatal outcomes. Coagulation function screening during pregnancy and etiological identification of abnormalities are crucial. For patients with congenital coagulation factor deficiency, individualized diagnosis and treatment plans should be developed for the perinatal period, and multidisciplinary collaborative management can effectively ensure maternal and neonatal safety.

Key words: Pregnancy trimester, third, Factor Ⅺ deficiency, Activated partial thromboplastin time, Plasma therapy, Multi-disciplinary team