国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (2): 104-107.

• 综述 • 上一篇    下一篇

Twist基因与妇科肿瘤发生发展的关系

张莉莉,张淑兰   

  1. 110004 沈阳，中国医科大学附属盛京医院妇产科
  • 收稿日期:2009-06-30 修回日期:1900-01-01 出版日期:2010-04-15 发布日期:2010-04-15
  • 通讯作者: 张淑兰

The Research Progresses on Twist in the Genesis and Progression of Gynecology Oncology

ZHANG Li-li, ZHANG Shu-lan   

  1. Department of Obstetrics and Gynecology, the Affiliated Shengjing Hospital of China Medical University, Shenyang 110004, China
  • Received:2009-06-30 Revised:1900-01-01 Published:2010-04-15 Online:2010-04-15
  • Contact: ZHANG Shu-lan

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摘要： Twist属于碱性的螺旋－环－螺旋蛋白家族，是一种高度保守的转录因子，在胚胎的发生发展中发挥重要作用，作为上皮-间质转变（EMT）过程中的关键调控因子，对肿瘤的侵袭，转移及耐药有重要影响。随着妇科肿瘤的发生和发展，Twist的表达逐渐增强，诱导肿瘤细胞发生EMT，使肿瘤呈现恶性表型，导致预后不良。现就Twist分子生物学特点、在肿瘤细胞中的信号转导途径和功能，及其在妇科肿瘤中的研究现状做文献综述。

关键词: Twist, 上皮－间质转变, 宫颈癌, 卵巢癌, 子宫内膜癌

Abstract: Twist is an evolutionarily conserved basic helix-loop-helix transcription factor. It has been found to play a key role in embryonic morphogenesis and the progression of primary tumor invasion, metastasis and drug resistance by inducing epithelial-mesenchymal transition. With the oncogenesis and development of gynecological neoplasms, twist has an increasing expression, inducing the epithelial-mesenchymal transition and leading to malignant phenotype and poor prognosis. In this review, the molecular biological characteristics, signal transduction pathway, function of twist on tumor cell and the research progresses on twist in the progression of gynecology oncology will be discussed comprehensively.

Key words: Twist, Epithelial-mesenchymal transition, Uterine cervical neoplasms, Ovarian neoplasms, Endometrial neoplasms