糖代谢与宫颈癌关系及其致病机制的研究进展

doi:10.12280/gjfckx.20230060

摘要/Abstract

摘要：

宫颈癌是我国女性最常见的生殖系统恶性肿瘤，其发病逐渐年轻化，严重威胁女性生命健康。多项研究表明，宫颈癌细胞发生能量代谢重新编程，即氧气充足时也利用糖酵解提供生物能量，这一改变与多个糖酵解酶、转运蛋白、调控分子和特定信号通路密切相关。糖代谢改变通过不同机制促进宫颈癌细胞的生长、增殖、迁移和侵袭等恶性过程，并且影响患者对放化疗的敏感性，分析该代谢过程相关蛋白表达可预测宫颈癌的预后，阻断其表达或可发挥抗癌作用。因此，糖酵解代谢相关蛋白有望成为宫颈癌治疗的潜在靶点。综述糖代谢参与宫颈癌发生、发展的病理机制，以期探讨针对能量代谢的新型治疗策略，为改善患者的治疗前景和延长生存期提供依据。

关键词: 宫颈肿瘤, 瓦尔堡效应, 肿瘤学, 糖酵解, 病理过程, 治疗

Abstract:

Cervical cancer is the most common malignant tumor of the reproductive system among women in China. Its incidence is gradually becoming younger, posing a serious threat to women′s life and health. Several studies have shown that energy metabolism is reprogramming in cervical cancer cells, which glycolysis is used to provide biological energy even if oxygen is sufficient. This change is closely related to multiple glycolytic enzymes, transporter proteins, regulatory molecules and specific signaling pathways. Alteration of glucose metabolism promotes malignant processes such as growth, proliferation, migration and invasion through different mechanisms in cervical cancer cells, and affects the sensitivity of the patients to radiotherapy and chemotherapy. Analysis of the expression of proteins related to this metabolic process can predict the prognosis of cervical cancer, and blocking its expression may have anti-cancer effects. Therefore, glycolytic metabolism-related proteins are expected to be potential targets for cervical cancer treatment. This paper reviews the pathological mechanism that glucose metabolism involves in the development and progression of cervical cancer, so as to explore novel therapeutic strategies for energy metabolism, and also provides basis for improving therapeutic prospect and prolonging the survival of the patients.

Key words: Uterine cervical neoplasms, Warburg effect, oncologic, Glycolysis, Pathologic processes, Therapy

马建红, 高亚婷, 万子华, 刘畅. 糖代谢与宫颈癌关系及其致病机制的研究进展[J]. 国际妇产科学杂志, 2023, 50(3): 275-280.

MA Jian-hong, GAO Ya-ting, WAN Zi-hua, LIU Chang. Research Progress in Relationship and Pathogenesis between Glucose Metabolism and Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2023, 50(3): 275-280.

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