国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (2): 194-195.

• 论著 • 上一篇    下一篇

血清CA19-9及CA125测定诊断子宫内膜异位症


张 清 , 洛若愚,徐 翊 , 李 华, 黄 鹂   

  1. 430060 武汉大学人民医院妇科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-04-15 发布日期:2012-04-15
  • 通讯作者: 洛若愚

The Clinlical Value of CA19-9 Verses CA125 in Diagnosis of Endometriosis

ZHANG Qing，LUO Ruo-yu，XU Yi，LI Hua，HUANG Li   

  1. Department of Gynecology，Renmin Hospital of Wuhan University，Wuhan 430060，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-04-15 Online:2012-04-15
  • Contact: LUO Ruo-yu

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摘要： 目的：探讨血清 CA19-9及CA125测定对子宫内膜异位症（EMs）的诊断价值。方法：采用放射免疫法测定55例EMs患者血清CA19-9及CA125水平，并与同期门诊健康妇女（对照组）进行比较。结果：EMs组及对照组血清CA19-9和CA125检测值的中位数及阳性率分别为27.81 U/mL、43.6%，11.78 U/mL、0和24.2 U/mL、36.3%，9.02 U/mL、4.0%。两组间差异均有统计学意义（均P＜0.05）。中重度（Ⅲ～Ⅳ期）EMs患者与轻度（Ⅰ～Ⅱ期）患者血清CA19-9和CA125中位数和阳性率分别为42.38 U/mL、57.9%，17.36 U/mL、11.8%和34.75 U/mL、50.0%，15.3 U/mL、5.9%，不同分期间差异有统计学意义（均P＜0.05）。血清CA19-9和CA125诊断EMs的敏感度、特异度及准确度分别为43.6%、100%、61.25%及36.3%、 96.0%、 55.0%。结论：血清CA125和CA19-9 在EMs患者中均有明显升高，测定两种血清标记物水平可协助EMs的诊断；两者血清水平与EMs患者病情程度有关。

关键词: 子宫内膜异位症, CA19-9抗原, CA125抗原, 诊断

Abstract: Objective：To investigate the diagnostic values of CA19-9 and CA125 in the serum for endometriosis. Methods：CA19-9 and CA125 serum levels were determined with RIA in 55 patients with endometriosis and 25 control healthy women. Results：the mean serum levels and positive rate of CA19-9 and CA125 for endometriosis and controls are 27.81 U/mL、43.6%，11.78 U/mL，0 and 24.2 U/mL、36.3%， 9.02 U/mL，4.0%，respectively. There is significant difference between the measure result and positive rate of CA19-9 and CA125 for endometriosis group and control（P＜0.05）. The mean serum levels of CA19-9 and CA125 in patients at stages Ⅲ～Ⅳ and Ⅰ～Ⅱ，according to the Revised American Fertility Society（R-AFS） classification，are 42.38 U/mL、57.9%，17.36 U/mL、11.8% and 34.75 U/mL、50.0%，15.3 U/mL、5.9%. The difference of the mean serum levels and positive rate between the groups is significant（P＜0.05）. The sensitivity，specificity and accuracy of CA19-9 and CA125 serum levels in diagnosis of endometriosis are 43.6%，100% and 61.25%；36.3%，96.0% and 55.0%，respectively. Conclusions：Measure the levels of CA19-9 and CA125 in serum can raise the sensitivity of diagnosis for endometriosis. The predictive values of CA19-9 and CA125 seem high only to predict severe（stages Ⅲ and Ⅳ） disease.

Key words: Endometriosis, CA19-9 antigen, CA125 antigen, Diagnosis