卵巢颗粒细胞凋亡在多囊卵巢综合征中的调控机制及中医药干预研究进展

doi:10.12280/gjfckx.20240741

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是自青春期起至绝经前后影响女性终身生殖健康的内分泌代谢疾病。PCOS的临床表现、生化特征和发病机制的异质性使其研究较为复杂。目前研究显示，卵泡发育异常与PCOS患者的卵巢颗粒细胞凋亡增加密切相关，改变颗粒细胞异常凋亡的病理状态可以通过干预胰岛素抵抗（insulin resistance，IR）调控卵巢激素微环境，拮抗氧化应激状态，调节炎症因子及脂代谢，进而影响PCOS进程。中医药具有协同多靶点、多通路干预卵巢颗粒细胞凋亡的优势。综述中医药通过干预IR、高雄激素血症、氧化应激、慢性低度炎症和脂质代谢异常等机制调控卵巢颗粒细胞凋亡进而影响PCOS的研究进展，以期为临床防治PCOS提供理论依据。

关键词: 多囊卵巢综合征, 粒层细胞, 细胞凋亡, 中药, 治疗

Abstract:

Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disease that affects female reproductive health throughout her life from the onset of puberty to pre- and post- menopause. The study of PCOS is complicated due to the heterogeneity of clinical manifestations, biochemical characteristics and pathogenesis. The current study shows that the abnormal follicular development is closely related to the increased apoptosis of ovarian granulosa cells in PCOS patients, which changes the pathological state of abnormal apoptosis of granulosa cells and can affect the process of PCOS by intervening insulin resistance (IR), regulating ovarian hormone microenvironment, antagonizing the state of oxidative stress, regulating inflammatory factors and lipid metabolism. Traditional Chinese medicine has the advantages of synergistic multiple targets, multi-pathway intervention in ovarian granulosa cell apoptosis. This article tries to retrieve and summarize relevant literature from domestic and abroad, review the intervention of IR, hyperandrogenism, oxidative stress, chronic low-grade inflammation and lipid metabolism mechanism regulation of PCOS, in order to provide a theoretical basis for clinical prevention and treatment of PCOS.

Key words: Polycystic ovary syndrome, Granulosa cells, Apoptosis, Traditional Chinese drugs, Therapy

李东楠, 向蓉, 汪海洋, 孙淼. 卵巢颗粒细胞凋亡在多囊卵巢综合征中的调控机制及中医药干预研究进展[J]. 国际妇产科学杂志, 2024, 51(6): 692-697.

LI Dong-nan, XIANG Rong, WANG Hai-yang, SUN Miao. Regulatory Mechanism of Ovarian Granulosa Cell Apoptosis in Polycystic Ovary Syndrome with Progress in Traditional Chinese Medicine[J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 692-697.

图/表 1

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