国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (1): 104-107.

• 综述 • 上一篇    下一篇

子宫内膜癌的孕激素拮抗及增敏机制

刘瑶，王玉东   

  1. 200030 上海交通大学医学院附属国际和平妇幼保健院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-02-15 发布日期:2015-02-15
  • 通讯作者: 王玉东

Progesterone Resistance and Sensitization Mechanisms of Endometrial Carcinoma

LIU Yao，WANG Yu-dong   

  1. Shanghai Jiao Tong University School of Medicine，The International Peace Maternity and Child Health Hospital，Shanghai 200030，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-02-15 Online:2015-02-15
  • Contact: WANG Yu-dong

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摘要： 子宫内膜癌是女性生殖道最常见的恶性肿瘤之一，近年来发病率逐渐上升并呈年轻化趋势。虽然子宫内膜癌大多发生于绝经后妇女，但也有约25%的患者发生于绝经前，其中40岁以下患者占3%～14%。然而，子宫内膜癌的标准手术疗法使年轻患者失去了生育机会及卵巢内分泌功能，严重影响患者的生活质量。目前，为了满足年轻患者保留生育能力的强烈愿望，长期应用大剂量孕激素的保守疗法成为治疗子宫内膜不典型增生及子宫内膜癌的重要方法。但是部分患者在治疗的不同时期出现孕激素拮抗现象，降低了激素治疗的效果，影响患者的预后。因此，进一步研究子宫内膜癌的孕激素拮抗及增敏机制，对提高早期子宫内膜癌的疗效以及保留生殖内分泌功能具有重要意义。综述子宫内膜癌的孕激素拮抗机制及其增敏途径。

关键词: 子宫内膜肿瘤, 孕激素类, 孕酮, 治疗

Abstract: Endometrial carcinoma（EC） is one of the most common malignant female genital carcinomas，and the incidence has been increased recently. Although it occurs mainly in the postmenopausal women，there are still 25% patients are premenopausal and 3%-14% patients are below 40 years old. Nevertheless，the standard surgical treatment is associated with the loss of their ability to fertility and the endocrine function of the ovaries among young women，which seriously affect the quality of their life. Nowadays，to preserve the fertility for the younger EC patients，the long-term use of high-dose progesterone is the main therapy of atypical endometrial hyperplasia and EC. However，progesterone resistance appears in many cases during the different stages，which reduces the effect of hormone therapy and influences the patients′ prognosis. Therefore，the further study of progesterone resistance and sensitization mechanisms is of great significance to improve the curative effect and preserve the fertility and endocrine function for the early stage EC patients. This article reviewed the progesterone resistance mechanisms and sensitizing ways of EC.

Key words: Endometrial neoplasms, Progestins, Progesterone, Therapy