国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (2): 125-128.

• 综述 •    下一篇

miR-124在妇科恶性肿瘤中的研究进展

刘芳丽，郝敏，赵卫红   

  1. 030001 太原，山西医科大学第二医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-04-15 发布日期:2015-04-15
  • 通讯作者: 郝敏

Research Progress of miR-124 in Gynecological Malignant Tumors

LIU Fang-li，HAO Min，ZHAO Wei-hong   

  1. Department of Obstetrics and Gynecology，The Second Hospital of Shanxi Medical University，Taiyuan 030001，China .
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-04-15 Online:2015-04-15
  • Contact: HAO Min

PDF (PC)

5445

被引次数

12

摘要： 微小RNA（microRNA，miRNA）是内源性单链非编码RNA，通过与靶基因互补结合产生转录后沉默的作用。近年来大量研究表明，多种肿瘤的发生与miR-124 表达异常有关，miR-124在抑制细胞增殖、促进细胞凋亡、抑制侵袭转移等方面发挥重要的抑癌作用。研究发现，miR-124在多种恶性肿瘤细胞系及实体组织中均呈低表达，且与肿瘤的发生、发展密切相关。近年关于miR-124在妇科恶性肿瘤中作用的研究日益增多，但其相关机制仍有待进一步研究。现对miR-124的生物学功能及其在妇科恶性肿瘤中的研究进展进行综述。

关键词: 微RNAs, 宫颈肿瘤, 子宫内膜肿瘤, 卵巢肿瘤

Abstract: MicroRNA (miRNA) are endogenous single-stranded noncoding RNA, which generating the role of transcriptional silencing by complementary binding to the target genes. In recent years, a large number of studies have shown that the occurrence of wide variety of tumor associated with abnormal expression of miR-124, which plays an important role in inhibiting of cell proliferation, promoting apoptosis and inhibiting the invasion and metastasis of tumor. Researches have revealed that miR-124 is remarkably down-regulated in many tumor cells and ontic tissues, and is closely related to the occurrence and development of tumor. In recent years, the study of the role of miR-124 in gynecological malignant tumor is increasing, but its mechanism still need further research. This article elaborates biological function of miR-124 and improvements of studies in gynecological malignant tumors.

Key words: MicroRNAs, Uterine cervical neoplasms, Endometrial neoplasms, Ovarian neoplasms