国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (2): 129-132.

• 综述 • 上一篇    下一篇

Matriptase与子宫内膜癌侵袭转移相关性的研究进展

薛丽芳，孙蓬明，项双卫   

  1. 350000 福州，福建省妇幼保健院妇科肿瘤实验室（薛丽芳，孙蓬明）；福建医科大学附属协和医院妇产科（项双卫）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-04-15 发布日期:2015-04-15
  • 通讯作者: 孙蓬明

Progress of the Correlation about Matriptase and the Invasion and Metastasis of Endometrial Cancer

XUE Li-fang，SUN Peng-ming，XIANG Shuang-wei   

  1. Laboratory of Gynecologic Oncology，Fujian Maternal and Children Hospital，Fuzhou 350000，China（XUE Li-fang，SUN Peng-ming）；Department of Obstetrics and Gynecology，Fujian Medical University Union Hospital，Fuzhou 350000，China（XIANG Shuang-wei）
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-04-15 Online:2015-04-15
  • Contact: SUN Peng-ming

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摘要： 侵袭和转移是恶性肿瘤的重要生物学特征之一，也是造成肿瘤患者死亡的主要原因。肿瘤的侵袭和转移是一个复杂的病理过程，涉及多种蛋白酶，包括基质金属蛋白酶和丝氨酸蛋白酶等。近来研究发现一种Ⅱ型跨膜丝氨酸蛋白酶Matriptase可通过激活尿激酶型纤溶酶原激活物、肝细胞生长因子/扩散因子、蛋白酶活化受体2和前列腺蛋白酶原促进肿瘤细胞的侵袭和转移，与多种恶性肿瘤，如乳腺癌、食管癌、前列腺癌、宫颈癌、卵巢癌、子宫内膜癌等的发生、发展密切相关。因而Matriptase有望成为恶性肿瘤一个新的诊断和治疗靶标。综述Matriptase与子宫内膜癌侵袭转移的相关性。

关键词: 丝氨酸内肽酶类, 子宫内膜肿瘤, 肿瘤转移

Abstract: Invasion and metastasis is one of the important biological features of malignant tumor, which leads to the cancer patients deaths. Tumor invasion and metastasis is a complex pathological process involving many kinds of protease which including metal matrix protease, serine protease and so on. Recently, we found a type Ⅱ transmembrane serine protease named Matriptase which can enhance the process of tumor invasion and metastasis through activating urokinase-type plasminogen activator, hepatocyte growth factor/scatter factor, protease activated receptor 2 and prostate. It was closely related to the occurrence and development of a variety of malignant tumors, such as breast cancer, esophageal cancer, prostate cancer, cervical cancer, ovarian cancer and endometrial cancer. Thus, Matriptase is expected to become a new biomarker for tumor diagnosis and a promising treatment target. Now we will discuss the correlation about Matriptase and the invasion and metastasis of endometrial cancer.

Key words: Serine endopeptidases, Endometrial neoplasms, Neoplasm metastasis